The total synthesis of the annonaceous acetogenin, muricatetrocin C

Darren J. Dixon, Steven V. Ley, Dominic J. Reynolds

    Research output: Contribution to journalArticlepeer-review


    The total synthesis of the potential antitumour agent muricatetrocin C has provided an ideal stage for the exploitation and development of new chemistry. A convergent synthetic strategy has been realised incorporating three distinct pieces of methodology, these include a highly diastereoselective hetero-Diels -Alder reaction to construct the butenolide terminus, an oxygen to carbon rearrangement to install the trans-2,5-disubstituted tetrahydrofuran ring and a spatial desymmetrisation process to afford the anti-diol unit.
    Original languageEnglish
    Pages (from-to)1621-1636
    Number of pages15
    JournalChemistry - A European Journal
    Issue number7
    Publication statusPublished - 2 Apr 2002


    • Antitumor agents
    • Cycloaddition
    • Natural products
    • Total synthesis


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