The UbiX-UbiD system: The biosynthesis and use of prenylated flavin (prFMN)

Stephen A. Marshall, Karl A.P. Payne, David Leys

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    Abstract

    The UbiX-UbiD system consists of the flavin prenyltransferase UbiX that produces prenylated FMN that serves as the cofactor for the (de)carboxylase UbiD. Recent developments have provided structural insights into the mechanism of both enzymes, detailing unusual chemistry in each case. The proposed reversible 1,3-dipolar cycloaddition between the cofactor and substrate serves as a model to explain many of the key UbiD family features. However, considerable variation exists in the many branches of the UbiD family tree.

    Original languageEnglish
    JournalArchives of Biochemistry and Biophysics
    Early online date25 Jul 2017
    DOIs
    Publication statusPublished - 2017

    Keywords

    • (de)Carboxylase
    • Cycloaddition
    • Prenyl transferase
    • Prenylated FMN
    • UbiD
    • UbiX

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