The unrecognized prevalence of chronic kidney disease in diabetes

Rachel J. Middleton, Robert N. Foley, Janet Hegarty, Ching M. Cheung, Patrick McElduff, J. Martin Gibson, Philip A. Kalra, Donal J. O'Donoghue, John P. New

    Research output: Contribution to journalArticlepeer-review


    Background: Diabetes mellitus and chronic kidney disease (CKD) are common and exhibit synergistic associations with premature mortality. Current diabetes guidelines in the UK recommend annual urinary albumin and serum creatinine determinations to screen for diabetic kidney disease. The aim of this study was to estimate the burden of CKD in patients with diabetes and examine the ability of serum creatinine and albuminuria to detect clinically meaningful CKD compared with estimated glomerular filtration rate (eGFR). Methods: All adults known to have diabetes in primary and secondary care in Salford, UK, alive with independent renal function on 1 January 2004 were included in this observational study (n = 7596). Demographic and laboratory parameters were obtained from the Electronic Patient Record. eGFR was determined using the 4-variable modification of diet in renal disease (MDRD) formula. Clinically meaningful CKD was defined as an eGFR
    Original languageEnglish
    Pages (from-to)88-92
    Number of pages4
    JournalNephrology, Dialysis, Transplantation
    Issue number1
    Publication statusPublished - Jan 2006


    • Diabetic kidney disease
    • Estimated glomerular filtration rate
    • Modification of diet in renal disease (MDRD) study equation
    • Sensitivity
    • Serum creatinine


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