The use of carboxylic acids as traceless directing groups for regioselective C-H bond functionalisation

Marc Font Molins, Jacob Quibell, Gregory Perry, Igor Larrosa

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The ability to selectively functionalise a specific C-H bond is a long-standing challenge due to the ubiquity of such bonds in organic molecules. One of the most common approaches to overcome this obstacle consists of installing directing groups into substrates to direct the functionalisation towards the desired C-H bond, leaving behind the directing group in the molecule. Alternatively, carboxylic acids have been employed as traceless directing groups that are easily removed after carboxylic acid-directed installation of the desired functionality. This review focuses on the development of this concept and its application to organic synthesis during the last decade.

    Original languageEnglish
    Pages (from-to)5584-5597
    Number of pages14
    JournalChemical Communications
    Volume53
    Issue number41
    Early online date28 Apr 2017
    DOIs
    Publication statusPublished - 2017

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