The use of microbeams to investigate radiation damage in living cells.

Melvyn Folkard; Kevin M Prise; Geoff Grime; Karen Kirkby; Borivoj Vojnovic

doi:10.1016/j.apradiso.2008.06.015

The use of microbeams to investigate radiation damage in living cells.

Melvyn Folkard, Kevin M Prise, Geoff Grime, Karen Kirkby, Borivoj Vojnovic

Research output: Contribution to journal › Article › peer-review

Abstract

The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no energy is deposited in the genomic DNA of the irradiated cell (i.e. by targeting just the cytoplasm).

Original language	English
Journal	Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Volume	67
Issue number	3
DOIs	https://doi.org/10.1016/j.apradiso.2008.06.015
Publication status	Published - Mar 2009

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10.1016/j.apradiso.2008.06.015

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title = "The use of microbeams to investigate radiation damage in living cells.",

abstract = "The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no energy is deposited in the genomic DNA of the irradiated cell (i.e. by targeting just the cytoplasm).",

author = "Melvyn Folkard and Prise, {Kevin M} and Geoff Grime and Karen Kirkby and Borivoj Vojnovic",

note = "A7047, Cancer Research UK, United Kingdom, Cancer Research UK, United Kingdom",

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AU - Folkard, Melvyn

AU - Prise, Kevin M

AU - Grime, Geoff

AU - Kirkby, Karen

AU - Vojnovic, Borivoj

N1 - A7047, Cancer Research UK, United Kingdom, Cancer Research UK, United Kingdom

PY - 2009/3

Y1 - 2009/3

N2 - The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no energy is deposited in the genomic DNA of the irradiated cell (i.e. by targeting just the cytoplasm).

AB - The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no energy is deposited in the genomic DNA of the irradiated cell (i.e. by targeting just the cytoplasm).

U2 - 10.1016/j.apradiso.2008.06.015

DO - 10.1016/j.apradiso.2008.06.015

M3 - Article

C2 - 18710814

SN - 1872-9800

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JO - Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

JF - Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

IS - 3

ER -

The use of microbeams to investigate radiation damage in living cells.

Abstract

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