TY - JOUR
T1 - The utility of established prognostic scores in COVID-19 hospital admissions: A multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA
AU - Bradley, Patrick
AU - Frost, Freddy
AU - Tharmaratnam, Kukatharmini
AU - Wootton, Dan Gower
AU - Ahmad, Mahin
AU - Aigbirior, Joshua
AU - Bull, Alex
AU - Cade, Ruth
AU - Grant, Kate
AU - King, Charlotte
AU - Kumar, Ayesha
AU - Kutubuddin, Farheen
AU - Liatsikos, Konstantinos
AU - Mir, Muhammed Haris
AU - Nasr, Eman
AU - Pearmain, Laurence
AU - Penfold, Rachel
AU - Raghunath, Sarika
AU - Randles, Victoria
AU - Robinson, Ryan
AU - Wang, Ran
PY - 2020/7/18
Y1 - 2020/7/18
N2 - Introduction The COVID-19 pandemic is ongoing yet, due to the lack of a COVID-19 specific tool, clinicians must use pre-existing illness severity scores for initial prognostication. However, the validity of such scores in COVID-19 is unknown. Methods The North West Collaborative Organization for Respiratory Research (NW-CORR) performed a multi-centre prospective evaluation of adult patients admitted to hospital with confirmed COVID-19 during a two-week period in April 2020. Clinical variables measured as part of usual care at presentation to hospital were recorded, including the CURB-65, NEWS2, and qSOFA scores. The primary outcome of interest was 30-day mortality. Results Data were collected for 830 people with COVID-19 admitted across 7 hospitals. By 30 days, a total of 300 (36.1%) had died and 142 (17.1%) had been in ICU. All scores underestimated mortality compared to their original validation in non-COVID-19 populations, and overall prognostic performance was generally poor. Among the ‘low risk’ categories (CURB-65
AB - Introduction The COVID-19 pandemic is ongoing yet, due to the lack of a COVID-19 specific tool, clinicians must use pre-existing illness severity scores for initial prognostication. However, the validity of such scores in COVID-19 is unknown. Methods The North West Collaborative Organization for Respiratory Research (NW-CORR) performed a multi-centre prospective evaluation of adult patients admitted to hospital with confirmed COVID-19 during a two-week period in April 2020. Clinical variables measured as part of usual care at presentation to hospital were recorded, including the CURB-65, NEWS2, and qSOFA scores. The primary outcome of interest was 30-day mortality. Results Data were collected for 830 people with COVID-19 admitted across 7 hospitals. By 30 days, a total of 300 (36.1%) had died and 142 (17.1%) had been in ICU. All scores underestimated mortality compared to their original validation in non-COVID-19 populations, and overall prognostic performance was generally poor. Among the ‘low risk’ categories (CURB-65
UR - https://www.mendeley.com/catalogue/5ea735cb-436f-3adc-956e-2f5852fce567/
U2 - 10.1101/2020.07.15.20154815
DO - 10.1101/2020.07.15.20154815
M3 - Article
SN - 2052-4439
JO - BMJ Open Respiratory Research
JF - BMJ Open Respiratory Research
ER -