The winding road for carbon nanotubes in nanomedicine

Silvia Marchesan; Kostas Kostarelos; Alberto Bianco; Maurizio Prato

doi:10.1016/j.mattod.2014.07.009

The winding road for carbon nanotubes in nanomedicine

Silvia Marchesan, Kostas Kostarelos, Alberto Bianco, Maurizio Prato

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Abstract

Carbon nanotubes (CNTs) are recognized as promising nanomaterials for technological advancement. However, the stigma of structural similarity with asbestos fibers has slowed down progress of CNTs in nanomedicine. Nevertheless, it also prompted thorough studies that have revealed that functionalized CNTs (fCNTs) can biologically behave in a very different and safer manner. Here we review pristine and fCNT fate in biological settings, focusing on the importance of protein interaction, formation of the protein corona, and modulation of immune response. The emerging consensus on the desirable fCNT properties to achieve immunological neutrality, and even biodegradation, shows great promise for CNT adoption in medicine.

Original language	English
Pages (from-to)	12-19
Journal	Materials Today
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.mattod.2014.07.009
Publication status	Published - 2015

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title = "The winding road for carbon nanotubes in nanomedicine",

abstract = "Carbon nanotubes (CNTs) are recognized as promising nanomaterials for technological advancement. However, the stigma of structural similarity with asbestos fibers has slowed down progress of CNTs in nanomedicine. Nevertheless, it also prompted thorough studies that have revealed that functionalized CNTs (fCNTs) can biologically behave in a very different and safer manner. Here we review pristine and fCNT fate in biological settings, focusing on the importance of protein interaction, formation of the protein corona, and modulation of immune response. The emerging consensus on the desirable fCNT properties to achieve immunological neutrality, and even biodegradation, shows great promise for CNT adoption in medicine.",

author = "Silvia Marchesan and Kostas Kostarelos and Alberto Bianco and Maurizio Prato",

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AU - Marchesan, Silvia

AU - Kostarelos, Kostas

AU - Bianco, Alberto

AU - Prato, Maurizio

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AB - Carbon nanotubes (CNTs) are recognized as promising nanomaterials for technological advancement. However, the stigma of structural similarity with asbestos fibers has slowed down progress of CNTs in nanomedicine. Nevertheless, it also prompted thorough studies that have revealed that functionalized CNTs (fCNTs) can biologically behave in a very different and safer manner. Here we review pristine and fCNT fate in biological settings, focusing on the importance of protein interaction, formation of the protein corona, and modulation of immune response. The emerging consensus on the desirable fCNT properties to achieve immunological neutrality, and even biodegradation, shows great promise for CNT adoption in medicine.

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The winding road for carbon nanotubes in nanomedicine

Abstract

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