Theoretical and experimental studies of linear sweep voltammetry in the rat brain

W. John Albery, Nicholas J. Goddard, T. William Beck, Marianne Fillenz, Robert D. O'Neill

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Theoretical expressions are derived for the current voltage peaks obtained using linear sweep voltammetry when the electroactive substance is consumed from a restricted compartment. The dissortion to the peaks caused by a Sallen and Key filter set to a low cut off frequency is also calculated. Results from carbon paste electrodes implanted in freely moving rats for periods of months are shown to be in good agreement with respect to the peak height, the peak potential, the peak width and the asymmetric shape of the peak. It is shown that the restricted compartment can be used to good advantage since the large interfering signal from ascorbate can be removed by electrolysis, allowing the measurement of neuroregulator metabolites such as 5-hydroxyindoleacetic acid and homovanillic acid. © 1984.
    Original languageEnglish
    Pages (from-to)221-233
    Number of pages12
    JournalJournal of Electroanalytical Chemistry
    Volume161
    Issue number2
    Publication statusPublished - 24 Feb 1984

    Keywords

    • Neurohormones Role: ANT (Analyte), ANST (Analytical study) (detn. of, in brain, linear-sweep voltammetry for)
    • Brain (neuroregulator metabolites of, detn. of, by linear-sweep voltammetry)
    • Voltammetry (linear-sweep, of brain, theor. and exptl. studies of)
    • linear sweep voltammetry neurohormone brain

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