Therapy of deep fungal infection in haematological malignancy: working party of the British society for antimicrobial chemotherapy

Rosemary A. Barnes; T. R.F. Rogers; J. Cohen; D. W. Denning; E. G.V. Evans; R. J. Hay; A. G. Prentice; D. C.E. Speller; D. W. Warnock; R. E. Warren

doi:10.1093/jac/40.6.779

Therapy of deep fungal infection in haematological malignancy: working party of the British society for antimicrobial chemotherapy

Rosemary A. Barnes^*, T. R.F. Rogers, J. Cohen, D. W. Denning, E. G.V. Evans, R. J. Hay, A. G. Prentice, D. C.E. Speller, D. W. Warnock, R. E. Warren

^*Corresponding author for this work

Division of Evolution, Infection and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

The treatment of deep fungal infection in haematological malignancy remains controversial due to the limited number of antifungal agents available and problems over their spectrum and dose-limiting side-effects. Difficulties in diagnosis mean that most treatments are begun empirically; amphotericin B remains the drug of choice. Emerging resistance may limit the usefulness of fluconazole and other azoles in some areas. Lipid preparations of amphotericin B have reduced the toxicity of this agent, but some issues of dosage and efficacy remain. Adjunctive treatments aimed at augmenting the host response to infection may have a role to play in deep fungal infection.

Original language	English
Pages (from-to)	779-788
Number of pages	10
Journal	Journal of Antimicrobial Chemotherapy
Volume	40
Issue number	6
DOIs	https://doi.org/10.1093/jac/40.6.779 https://doi.org/10.1093/jac/40.6.779
Publication status	Published - 1 Dec 1997

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Barnes, R. A., Rogers, T. R. F., Cohen, J., Denning, D. W., Evans, E. G. V., Hay, R. J., Prentice, A. G., Speller, D. C. E., Warnock, D. W., & Warren, R. E. (1997). Therapy of deep fungal infection in haematological malignancy: working party of the British society for antimicrobial chemotherapy. Journal of Antimicrobial Chemotherapy, 40(6), 779-788. https://doi.org/10.1093/jac/40.6.779, https://doi.org/10.1093/jac/40.6.779

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abstract = "The treatment of deep fungal infection in haematological malignancy remains controversial due to the limited number of antifungal agents available and problems over their spectrum and dose-limiting side-effects. Difficulties in diagnosis mean that most treatments are begun empirically; amphotericin B remains the drug of choice. Emerging resistance may limit the usefulness of fluconazole and other azoles in some areas. Lipid preparations of amphotericin B have reduced the toxicity of this agent, but some issues of dosage and efficacy remain. Adjunctive treatments aimed at augmenting the host response to infection may have a role to play in deep fungal infection.",

author = "Barnes, {Rosemary A.} and Rogers, {T. R.F.} and J. Cohen and Denning, {D. W.} and Evans, {E. G.V.} and Hay, {R. J.} and Prentice, {A. G.} and Speller, {D. C.E.} and Warnock, {D. W.} and Warren, {R. E.}",

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Barnes, RA, Rogers, TRF, Cohen, J, Denning, DW, Evans, EGV, Hay, RJ, Prentice, AG, Speller, DCE, Warnock, DW & Warren, RE 1997, 'Therapy of deep fungal infection in haematological malignancy: working party of the British society for antimicrobial chemotherapy', Journal of Antimicrobial Chemotherapy, vol. 40, no. 6, pp. 779-788. https://doi.org/10.1093/jac/40.6.779, https://doi.org/10.1093/jac/40.6.779

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AU - Evans, E. G.V.

AU - Hay, R. J.

AU - Prentice, A. G.

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AU - Warnock, D. W.

AU - Warren, R. E.

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Therapy of deep fungal infection in haematological malignancy: working party of the British society for antimicrobial chemotherapy

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