Thermally reversible xyloglucan gels as vehicles for oral drug delivery

N. Kawasaki, R. Ohkura, S. Miyazaki, Y. Uno, S. Sugimoto, David Attwood

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The potential, as sustained release vehicles, of gels formed in situ following the oral administration of dilute aqueous solutions of a xyloglucan polysaccharide derived from tamarind seed has been assessed by in vitro and in vivo studies. Aqueous solutions of xyloglucan that had been partially degraded by β-galactosidase to eliminate 44% of galactose residues formed rigid gels at concentrations of 1.0 and 1.5% w/w at 37°C. The in vitro release of indomethacin and diltiazem from the enzyme-degraded xyloglucan gels followed root-time kinetics over a period of 5 h at 37°C at pH 6.8. Plasma concentrations of indomethacin and diltiazem, after oral administration to rats of chilled 1% w/w aqueous solutions of the enzyme-degraded xyloglucan containing dissolved drug, and a suspension of indomethacin of the same concentration were compared. Constant indomethacin plasma concentrations were noted from both formulations after 2 h and were maintained over a period of at least 7 h. Bioavailability of indomethacin from xyloglucan gels formed in situ was increased approximately threefold compared with that from the suspension. The results of this study suggest the potential of the enzyme-degraded xyloglucan gels as vehicles for oral delivery of drugs. Copyright (C) 1999 Elsevier Science B.V.
    Original languageEnglish
    Pages (from-to)227-234
    Number of pages7
    JournalInternational Journal of Pharmaceutics
    Volume181
    Issue number2
    DOIs
    Publication statusPublished - 30 Apr 1999

    Keywords

    • Indomethacin
    • Oral drug delivery
    • Sustained release
    • Thermoreversible gels
    • Xyloglucan gels

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