Thermogenesis and sympathetic activity in BAT of overfed rats after adrenalectomy

D. Marchington, N. J. Rothwell, M. J. Stock, D. A. York

Research output: Contribution to journalArticlepeer-review


Resting oxygen consumption was elevated by 30% in young rats fed a cafeteria diet compared with their chow-fed controls and by 22% in cafeteria-fed, adrenalectomized (ADX) rats compared with the ADX chow-fed group, but injection of propranolol reduced oxygen consumption in the cafeteria-fed animals and abolished these differences. Brown adipose tissue (BAT) mass was increased by cafeteria feeding, and the activity of the mitochondrial proton conductance pathway (assessed from purine nucleotide binding) was enhanced by adrenalectomy and by cafeteria feeding. Norepinephrine turnover in BAT (determined from the time-dependent loss of tissue [3H]norepinephrine specific activity) was increased by 105% in sham-operated, cafeteria-fed rats, by 142% in chow-fed ADX rats, and by 400% in cafeteria-fed ADX rats, compared with chow-fed controls. Cardiac norepinephrine turnover was elevated by 80% in sham-operated, cafeteria-fed rats, but unaffected by adrenalectomy. These data indicate that the enhanced thermogenesis and BAT activity induced by adrenalectomy in chow- or cafeteria-fed rats is due to increased sympathetic activity in the tissue.
Original languageEnglish
Pages (from-to)13/4
JournalAJP: Endocrinology and Metabolism
Issue number4
Publication statusPublished - 1986


Dive into the research topics of 'Thermogenesis and sympathetic activity in BAT of overfed rats after adrenalectomy'. Together they form a unique fingerprint.

Cite this