Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies

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D-Fenfluramine is a potent stimulator of thermogenesis in the rat, an action which may contribute to its effects on body weight. The actions of D-fenfluramine appear to control release of endogenous 5-HT which subsequently induces release of eicosanoids and corticotrophin-releasing factor. Peripheral heat production results mainly from sympathetic activation of thermogenesis.
Original languageEnglish
Pages (from-to)S67-S71
JournalInternational Journal of Obesity
Issue number3
Publication statusPublished - 1992


  • 5-HT
  • Brown adipose tissue
  • Corticotrophin-releasing factor
  • Dexfenfluramine
  • Prostaglandins
  • Serotonin
  • Thermogenesis

Research Beacons, Institutes and Platforms

  • Manchester Institute of Biotechnology


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