Abstract
D-Fenfluramine is a potent stimulator of thermogenesis in the rat, an action which may contribute to its effects on body weight. The actions of D-fenfluramine appear to control release of endogenous 5-HT which subsequently induces release of eicosanoids and corticotrophin-releasing factor. Peripheral heat production results mainly from sympathetic activation of thermogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | S67-S71 |
| Journal | International Journal of Obesity |
| Volume | 16 |
| Issue number | 3 |
| Publication status | Published - 1992 |
Keywords
- 5-HT
- Brown adipose tissue
- Corticotrophin-releasing factor
- Dexfenfluramine
- Prostaglandins
- Serotonin
- Thermogenesis
Research Beacons, Institutes and Platforms
- Manchester Institute of Biotechnology