Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat

E. C. Griffiths, N. J. Rothwell, M. J. Stock

Research output: Contribution to journalArticlepeer-review

Abstract

Acute or chronic injection of RX 77368 (a TRH analogue; 1 mg/kg s.c.) stimulated oxygen consumption (VO2) and brown adipose tissue activity in the rat, and decreased weight gain Other TRH analogues (CG 3509, RGH 2202) and TRH itself also stimulated VO2. These thermogenic actions are probably mediated centrally by stimulation of sympathetic outflow to brown fat. © 1988 Birkhäuser Verlag Basel.
Original languageEnglish
Pages (from-to)40-42
Number of pages2
JournalExperientia
Volume44
Issue number1
DOIs
Publication statusPublished - Jan 1988

Keywords

  • brown adipose tissue
  • thermogenesis
  • TRH
  • TRH analogues

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