Thirteen novel canine dog leukocyte antigen-88 alleles identified by sequence-based typing

G. M. Venkataraman, L. J. Kennedy, M. -T. E. Little, S. S. Graves, M. A. Harkey, B. J. Torok-Storb, R. Storb

Research output: Contribution to journalArticlepeer-review

Abstract

Major histocompatibility complex (MHC) genes in mammals include highly polymorphic class I and class II genes that are critical for donor-recipient matching for transplantation. Dogs have served as an effective, directly translatable model for stem/progenitor cell transplantation. Previous analyses of MHC class I genes in dogs point to a single highly polymorphic gene, dog leukocyte antigen (DLA)-88, as an important factor in the success or failure of hematopoietic stem cell transplants. Fifty-nine DLA-88 alleles have been identified and reported so far. Here, we extend this list by presenting 13 novel DLA-88 alleles found in domestic dogs.
Original languageEnglish
Pages (from-to)165-170
JournalHLA
Volume90
Issue number3
Early online date5 Jul 2017
DOIs
Publication statusPublished - Sep 2017

Keywords

  • allele
  • canine
  • class I
  • DLA-88
  • dog
  • dog leukocyte antigen
  • major histocompatibility complex

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