Thirteen novel canine dog leukocyte antigen-88 alleles identified by sequence-based typing

G. M. Venkataraman; L. J. Kennedy; M. -T. E. Little; S. S. Graves; M. A. Harkey; B. J. Torok-Storb; R. Storb

doi:10.1111/tan.13077

Thirteen novel canine dog leukocyte antigen-88 alleles identified by sequence-based typing

G. M. Venkataraman, L. J. Kennedy, M. -T. E. Little, S. S. Graves, M. A. Harkey, B. J. Torok-Storb, R. Storb

Division of Population Health, Health Services Research & Primary Care (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Major histocompatibility complex (MHC) genes in mammals include highly polymorphic class I and class II genes that are critical for donor-recipient matching for transplantation. Dogs have served as an effective, directly translatable model for stem/progenitor cell transplantation. Previous analyses of MHC class I genes in dogs point to a single highly polymorphic gene, dog leukocyte antigen (DLA)-88, as an important factor in the success or failure of hematopoietic stem cell transplants. Fifty-nine DLA-88 alleles have been identified and reported so far. Here, we extend this list by presenting 13 novel DLA-88 alleles found in domestic dogs.

Original language	English
Pages (from-to)	165-170
Journal	HLA
Volume	90
Issue number	3
Early online date	5 Jul 2017
DOIs	https://doi.org/10.1111/tan.13077
Publication status	Published - Sept 2017

Keywords

allele
canine
class I
DLA-88
dog
dog leukocyte antigen
major histocompatibility complex

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10.1111/tan.13077

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title = "Thirteen novel canine dog leukocyte antigen-88 alleles identified by sequence-based typing",

abstract = "Major histocompatibility complex (MHC) genes in mammals include highly polymorphic class I and class II genes that are critical for donor-recipient matching for transplantation. Dogs have served as an effective, directly translatable model for stem/progenitor cell transplantation. Previous analyses of MHC class I genes in dogs point to a single highly polymorphic gene, dog leukocyte antigen (DLA)-88, as an important factor in the success or failure of hematopoietic stem cell transplants. Fifty-nine DLA-88 alleles have been identified and reported so far. Here, we extend this list by presenting 13 novel DLA-88 alleles found in domestic dogs.",

keywords = "allele, canine, class I, DLA-88, dog, dog leukocyte antigen, major histocompatibility complex",

author = "Venkataraman, {G. M.} and Kennedy, {L. J.} and Little, {M. -T. E.} and Graves, {S. S.} and Harkey, {M. A.} and Torok-Storb, {B. J.} and R. Storb",

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AU - Venkataraman, G. M.

AU - Kennedy, L. J.

AU - Little, M. -T. E.

AU - Graves, S. S.

AU - Harkey, M. A.

AU - Torok-Storb, B. J.

AU - Storb, R.

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N2 - Major histocompatibility complex (MHC) genes in mammals include highly polymorphic class I and class II genes that are critical for donor-recipient matching for transplantation. Dogs have served as an effective, directly translatable model for stem/progenitor cell transplantation. Previous analyses of MHC class I genes in dogs point to a single highly polymorphic gene, dog leukocyte antigen (DLA)-88, as an important factor in the success or failure of hematopoietic stem cell transplants. Fifty-nine DLA-88 alleles have been identified and reported so far. Here, we extend this list by presenting 13 novel DLA-88 alleles found in domestic dogs.

AB - Major histocompatibility complex (MHC) genes in mammals include highly polymorphic class I and class II genes that are critical for donor-recipient matching for transplantation. Dogs have served as an effective, directly translatable model for stem/progenitor cell transplantation. Previous analyses of MHC class I genes in dogs point to a single highly polymorphic gene, dog leukocyte antigen (DLA)-88, as an important factor in the success or failure of hematopoietic stem cell transplants. Fifty-nine DLA-88 alleles have been identified and reported so far. Here, we extend this list by presenting 13 novel DLA-88 alleles found in domestic dogs.

KW - allele

KW - canine

KW - class I

KW - DLA-88

KW - dog

KW - dog leukocyte antigen

KW - major histocompatibility complex

U2 - 10.1111/tan.13077

DO - 10.1111/tan.13077

M3 - Article

SN - 2059-2302

VL - 90

SP - 165

EP - 170

JO - HLA

JF - HLA

IS - 3

ER -

Thirteen novel canine dog leukocyte antigen-88 alleles identified by sequence-based typing

Abstract

Keywords

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