Thomas Addison's disease after 154 years: modern diagnostic perspectives on an old condition

L. Leelarathna; J. K. Powrie; P. V. Carroll

doi:10.1093/qjmed/hcp053

Thomas Addison's disease after 154 years: modern diagnostic perspectives on an old condition

L. Leelarathna, J. K. Powrie, P. V. Carroll

Division of Diabetes, Endocrinology & Gastroenterology (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Thomas Addison was first to describe adrenocortical failure in 1855. Despite advances in the treatment of this condition, the diagnosis is still often delayed and sometimes missed with potentially fatal consequences. From the same institution where Thomas Addison performed his original autopsy studies, we present four recent cases highlighting the wide clinical spectrum and discuss how modern biochemical and immunological tests could be utilized in early diagnosis and aetiological classification.

Original language	English
Pages (from-to)	569-573
Number of pages	5
Journal	QJM : monthly journal of the Association of Physicians
Volume	102
Issue number	8
DOIs	https://doi.org/10.1093/qjmed/hcp053
Publication status	Published - Aug 2009

Keywords

Addison Disease/diagnosis
Adrenal Cortex Hormones/metabolism
Adult
Anti-Inflammatory Agents/therapeutic use
Female
History, 19th Century
Humans
Hydrocortisone/therapeutic use
Male
Middle Aged

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10.1093/qjmed/hcp053

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title = "Thomas Addison's disease after 154 years: modern diagnostic perspectives on an old condition",

abstract = "Thomas Addison was first to describe adrenocortical failure in 1855. Despite advances in the treatment of this condition, the diagnosis is still often delayed and sometimes missed with potentially fatal consequences. From the same institution where Thomas Addison performed his original autopsy studies, we present four recent cases highlighting the wide clinical spectrum and discuss how modern biochemical and immunological tests could be utilized in early diagnosis and aetiological classification.",

keywords = "Addison Disease/diagnosis, Adrenal Cortex Hormones/metabolism, Adult, Anti-Inflammatory Agents/therapeutic use, Female, History, 19th Century, Humans, Hydrocortisone/therapeutic use, Male, Middle Aged",

author = "L. Leelarathna and Powrie, {J. K.} and Carroll, {P. V.}",

year = "2009",

month = aug,

doi = "10.1093/qjmed/hcp053",

language = "English",

volume = "102",

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journal = "QJM : monthly journal of the Association of Physicians",

issn = "1460-2725",

publisher = "Oxford University Press",

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T1 - Thomas Addison's disease after 154 years

T2 - modern diagnostic perspectives on an old condition

AU - Leelarathna, L.

AU - Powrie, J. K.

AU - Carroll, P. V.

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AB - Thomas Addison was first to describe adrenocortical failure in 1855. Despite advances in the treatment of this condition, the diagnosis is still often delayed and sometimes missed with potentially fatal consequences. From the same institution where Thomas Addison performed his original autopsy studies, we present four recent cases highlighting the wide clinical spectrum and discuss how modern biochemical and immunological tests could be utilized in early diagnosis and aetiological classification.

KW - Addison Disease/diagnosis

KW - Adrenal Cortex Hormones/metabolism

KW - Adult

KW - Anti-Inflammatory Agents/therapeutic use

KW - Female

KW - History, 19th Century

KW - Humans

KW - Hydrocortisone/therapeutic use

KW - Male

KW - Middle Aged

U2 - 10.1093/qjmed/hcp053

DO - 10.1093/qjmed/hcp053

M3 - Article

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SN - 1460-2725

VL - 102

SP - 569

EP - 573

JO - QJM : monthly journal of the Association of Physicians

JF - QJM : monthly journal of the Association of Physicians

IS - 8

ER -

Thomas Addison's disease after 154 years: modern diagnostic perspectives on an old condition

Abstract

Keywords

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