Three-Dimensional Reconstruction of the Cornea by Electron Tomography

Geraint  Parfitt; Christian Pinali; Philip Lewis; Robert D. Young; Andrew J.  Quantock; Carlo Knupp

doi:10.1002/micro.491/full/i52468c88a5672abeba5b89fea822bd8a.pdf

Three-Dimensional Reconstruction of the Cornea by Electron Tomography

Geraint Parfitt, Christian Pinali, Philip Lewis, Robert D. Young, Andrew J. Quantock, Carlo Knupp

Division of Cell Matrix Biology & Regenerative Medicine (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Corneal transparency is fundamental to vision and is attributed to the organised collagen fibril architecture the tissue maintains, which is regulated by proteoglycans. To understand the inter-relationships between collagen and proteoglycans in the cornea, three-dimensional reconstructions were obtained of mouse and bovine corneas which allow the conformations that proteoglycans adopt three-dimensionally to be observed for the first time.

Original language	English
Pages (from-to)	17-19
Number of pages	3
Journal	Microscopy and Analysis
DOIs	https://doi.org/10.1002/micro.491/full/i52468c88a5672abeba5b89fea822bd8a.pdf
Publication status	Published - Mar 2010

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title = "Three-Dimensional Reconstruction of the Cornea by Electron Tomography",

abstract = "Corneal transparency is fundamental to vision and is attributed to the organised collagen fibril architecture the tissue maintains, which is regulated by proteoglycans. To understand the inter-relationships between collagen and proteoglycans in the cornea, three-dimensional reconstructions were obtained of mouse and bovine corneas which allow the conformations that proteoglycans adopt three-dimensionally to be observed for the first time.",

author = "Geraint Parfitt and Christian Pinali and Philip Lewis and Young, {Robert D.} and Quantock, {Andrew J.} and Carlo Knupp",

year = "2010",

month = mar,

doi = "10.1002/micro.491/full/i52468c88a5672abeba5b89fea822bd8a.pdf",

language = "English",

pages = "17--19",

journal = "Microscopy and Analysis",

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T1 - Three-Dimensional Reconstruction of the Cornea by Electron Tomography

AU - Parfitt, Geraint

AU - Pinali, Christian

AU - Lewis, Philip

AU - Young, Robert D.

AU - Quantock, Andrew J.

AU - Knupp, Carlo

PY - 2010/3

Y1 - 2010/3

N2 - Corneal transparency is fundamental to vision and is attributed to the organised collagen fibril architecture the tissue maintains, which is regulated by proteoglycans. To understand the inter-relationships between collagen and proteoglycans in the cornea, three-dimensional reconstructions were obtained of mouse and bovine corneas which allow the conformations that proteoglycans adopt three-dimensionally to be observed for the first time.

AB - Corneal transparency is fundamental to vision and is attributed to the organised collagen fibril architecture the tissue maintains, which is regulated by proteoglycans. To understand the inter-relationships between collagen and proteoglycans in the cornea, three-dimensional reconstructions were obtained of mouse and bovine corneas which allow the conformations that proteoglycans adopt three-dimensionally to be observed for the first time.

U2 - 10.1002/micro.491/full/i52468c88a5672abeba5b89fea822bd8a.pdf

DO - 10.1002/micro.491/full/i52468c88a5672abeba5b89fea822bd8a.pdf

M3 - Article

SP - 17

EP - 19

JO - Microscopy and Analysis

JF - Microscopy and Analysis

ER -

Three-Dimensional Reconstruction of the Cornea by Electron Tomography

Abstract

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