Three-Dimensional Reconstruction of the Cornea by Electron Tomography

Geraint Parfitt, Christian Pinali, Philip Lewis, Robert D. Young, Andrew J. Quantock, Carlo Knupp

Research output: Contribution to journalArticlepeer-review


Corneal transparency is fundamental to vision and is attributed to the organised collagen fibril architecture the tissue maintains, which is regulated by proteoglycans. To understand the inter-relationships between collagen and proteoglycans in the cornea, three-dimensional reconstructions were obtained of mouse and bovine corneas which allow the conformations that proteoglycans adopt three-dimensionally to be observed for the first time.
Original languageEnglish
Pages (from-to)17-19
Number of pages3
JournalMicroscopy and Analysis
Publication statusPublished - Mar 2010


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