Three-way assessment of long-chain n-3 PUFA nutrition: By questionnaire and matched blood and skin samples

Sarah C. Wallingford, Suzanne M. Pilkington, Karen A. Massey, Naser M I Al-Aasswad, Torukiri I. Ibiebele, Maria Celia Hughes, Susan Bennett, Anna Nicolaou, Lesley E. Rhodes, Adèle C. Green

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The long-chain n-3 PUFA, EPA, is believed to be important for skin health, including roles in the modulation of inflammation and protection from photodamage. FFQ and blood levels are used as non-invasive proxies for assessing skin PUFA levels, but studies examining how well these proxies reflect target organ content are lacking. In seventy-eight healthy women (mean age 42·8, range 21-60 years) residing in Greater Manchester, we performed a quantitative analysis of long-chain n-3 PUFA nutrition estimated from a self-reported FFQ (n 75) and correlated this with n-3 PUFA concentrations in erythrocytes (n 72) and dermis (n 39). Linear associations between the three n-3 PUFA measurements were assessed by Spearman correlation coefficients and agreement between these measurements was estimated. Average total dietary content of the principal long-chain n-3 PUFA EPA and DHA was 171 (sd 168) and 236 (sd 248)Â mg/d, respectively. EPA showed significant correlations between FFQ assessments and both erythrocyte (r 0·57, P
Original languageEnglish
Pages (from-to)701-708
Number of pages7
JournalBritish Journal of Nutrition
Issue number4
Publication statusPublished - 28 Feb 2013


  • Correlations
  • Erythrocytes
  • FFQ
  • n-3 PUFA
  • Skin


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