Thrombosis in ovarian cancer: A case control study

Robert Metcalf; Derek Fry; R. Swindell; A. McGurk; A. R. Clamp; G. C. Jayson; J. Hasan

doi:10.1038/bjc.2014.3

Thrombosis in ovarian cancer: A case control study

Robert Metcalf, Derek Fry, R. Swindell, A. McGurk, A. R. Clamp, G. C. Jayson, J. Hasan

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Thrombotic events are common in cancer patients and have been associated with an adverse prognosis in large registry-based studies. Methods: A retrospective cohort of 417 patients with ovarian cancer treated at a tertiary cancer centre between 2006 and 2009 was studied to identify the incidence and risk factors for thrombotic events and the prognostic impact of thrombosis. Patient outcomes were evaluated against a matched control group without thrombosis. Results: Ninety-nine thrombotic events occurred in 90 patients (21.6%) from 8 months before diagnosis to 56 months following diagnosis, peaking in the 4 months following diagnosis. Patients with thrombosis were older (mean 65 vs 61 years, P=0.007), had a worse performance status (PS ≥2: 29.9% vs 9.5%, P

Original language	English
Pages (from-to)	1118-1124
Number of pages	6
Journal	British Journal of Cancer
Volume	110
Issue number	5
DOIs	https://doi.org/10.1038/bjc.2014.3
Publication status	Published - 4 Mar 2014

Keywords

Deep venous thrombosis
DVT
Ovarian cancer
PE
Pulmonary embolism
Thromboembolism

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/bjc.2014.3

http://www.nature.com/bjc/index.html

Cite this

@article{311159b1c566408eb42c8501c236c5ea,

title = "Thrombosis in ovarian cancer: A case control study",

abstract = "Background: Thrombotic events are common in cancer patients and have been associated with an adverse prognosis in large registry-based studies. Methods: A retrospective cohort of 417 patients with ovarian cancer treated at a tertiary cancer centre between 2006 and 2009 was studied to identify the incidence and risk factors for thrombotic events and the prognostic impact of thrombosis. Patient outcomes were evaluated against a matched control group without thrombosis. Results: Ninety-nine thrombotic events occurred in 90 patients (21.6%) from 8 months before diagnosis to 56 months following diagnosis, peaking in the 4 months following diagnosis. Patients with thrombosis were older (mean 65 vs 61 years, P=0.007), had a worse performance status (PS ≥2: 29.9% vs 9.5%, P",

keywords = "Deep venous thrombosis, DVT, Ovarian cancer, PE, Pulmonary embolism, Thromboembolism",

author = "Robert Metcalf and Derek Fry and R. Swindell and A. McGurk and Clamp, {A. R.} and Jayson, {G. C.} and J. Hasan",

year = "2014",

month = mar,

day = "4",

doi = "10.1038/bjc.2014.3",

language = "English",

volume = "110",

pages = "1118--1124",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "5",

}

TY - JOUR

T1 - Thrombosis in ovarian cancer: A case control study

AU - Metcalf, Robert

AU - Fry, Derek

AU - Swindell, R.

AU - McGurk, A.

AU - Clamp, A. R.

AU - Jayson, G. C.

AU - Hasan, J.

PY - 2014/3/4

Y1 - 2014/3/4

N2 - Background: Thrombotic events are common in cancer patients and have been associated with an adverse prognosis in large registry-based studies. Methods: A retrospective cohort of 417 patients with ovarian cancer treated at a tertiary cancer centre between 2006 and 2009 was studied to identify the incidence and risk factors for thrombotic events and the prognostic impact of thrombosis. Patient outcomes were evaluated against a matched control group without thrombosis. Results: Ninety-nine thrombotic events occurred in 90 patients (21.6%) from 8 months before diagnosis to 56 months following diagnosis, peaking in the 4 months following diagnosis. Patients with thrombosis were older (mean 65 vs 61 years, P=0.007), had a worse performance status (PS ≥2: 29.9% vs 9.5%, P

AB - Background: Thrombotic events are common in cancer patients and have been associated with an adverse prognosis in large registry-based studies. Methods: A retrospective cohort of 417 patients with ovarian cancer treated at a tertiary cancer centre between 2006 and 2009 was studied to identify the incidence and risk factors for thrombotic events and the prognostic impact of thrombosis. Patient outcomes were evaluated against a matched control group without thrombosis. Results: Ninety-nine thrombotic events occurred in 90 patients (21.6%) from 8 months before diagnosis to 56 months following diagnosis, peaking in the 4 months following diagnosis. Patients with thrombosis were older (mean 65 vs 61 years, P=0.007), had a worse performance status (PS ≥2: 29.9% vs 9.5%, P

KW - Deep venous thrombosis

KW - DVT

KW - Ovarian cancer

KW - PE

KW - Pulmonary embolism

KW - Thromboembolism

U2 - 10.1038/bjc.2014.3

DO - 10.1038/bjc.2014.3

M3 - Article

C2 - 24448364

SN - 0007-0920

VL - 110

SP - 1118

EP - 1124

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 5

ER -

Thrombosis in ovarian cancer: A case control study

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

Access to Document

Fingerprint

Cite this