Thyroid hormones and male sexual function

G. Corona; F. Wu; G. Forti; DM Lee; D. B. O'Connor; T. O'Neill; N. Pendleton; G. Bartfai; S. Boonen; F. Casanueva; J. Finn; A. Giwercman; T. S. Han; I. Huhtaniemi; K. Kula; M. E J Lean; M. Punab; D. Vanderschueren; E. A. Jannini; E. Mannucci; M. Maggi; L. Petrone; H. Borghs; J. Slowikowska-Hilczer; R. Walczak-Jedrzejowska; A. Silman; P. Steer; A. Tajar; S. Pye; M. Ocampo; M. Lage; I. Foldesi; I. Fejes; P. Korrovitz; M. Jiang

doi:10.1111/j.1365-2605.2012.01266.x

Thyroid hormones and male sexual function

G. Corona, F. Wu, G. Forti, DM Lee, D. B. O'Connor, T. O'Neill, N. Pendleton, G. Bartfai, S. Boonen, F. Casanueva, J. Finn, A. Giwercman, T. S. Han, I. Huhtaniemi, K. Kula, M. E J Lean, M. Punab, D. Vanderschueren, E. A. Jannini, E. MannucciM. Maggi, L. Petrone, H. Borghs, J. Slowikowska-Hilczer, R. Walczak-Jedrzejowska, A. Silman, P. Steer, A. Tajar, S. Pye, M. Ocampo, M. Lage, I. Foldesi, I. Fejes, P. Korrovitz, M. Jiang

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Abstract

The role of thyroid hormones in the control of erectile functioning has been only superficially investigated. The aim of the present study was to investigate the association between thyroid and erectile function in two different cohorts of subjects. The first one derives from the European Male Ageing Study (EMAS study), a multicentre survey performed on a sample of 3369 community-dwelling men aged 40-79years (mean 60±11years). The second cohort is a consecutive series of 3203 heterosexual male patients (mean age 51.8±13.0years) attending our Andrology and Sexual Medicine Outpatient Clinic for sexual dysfunction at the University of Florence (UNIFI study). In the EMAS study all subjects were tested for thyroid-stimulating hormone (TSH) and free thyroxine (FT4). Similarly, TSH levels were checked in all patients in the UNIFI study, while FT4 only when TSH resulted outside the reference range. Overt primary hyperthyroidism (reduced TSH and elevated FT4, according to the reference range) was found in 0.3 and 0.2% of EMAS and UNIFI study respectively. In both study cohorts, suppressed TSH levels were associated with erectile dysfunction (ED). Overt hyperthyroidism was associated with an increased risk of severe erectile dysfunction (ED, hazard ratio=14 and 16 in the EMAS and UNIFI study, respectively; both p

Original language	English
Pages (from-to)	668-679
Number of pages	11
Journal	International Journal of Andrology
Volume	35
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2605.2012.01266.x
Publication status	Published - Oct 2012

Keywords

Erectile dysfunction
Hypoactive sexual desire
Testosterone
Thyroid hormones

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10.1111/j.1365-2605.2012.01266.x

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Corona, G., Wu, F., Forti, G., Lee, DM., O'Connor, D. B., O'Neill, T., Pendleton, N., Bartfai, G., Boonen, S., Casanueva, F., Finn, J., Giwercman, A., Han, T. S., Huhtaniemi, I., Kula, K., Lean, M. E. J., Punab, M., Vanderschueren, D., Jannini, E. A., ... Jiang, M. (2012). Thyroid hormones and male sexual function. International Journal of Andrology, 35(5), 668-679. https://doi.org/10.1111/j.1365-2605.2012.01266.x

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title = "Thyroid hormones and male sexual function",

abstract = "The role of thyroid hormones in the control of erectile functioning has been only superficially investigated. The aim of the present study was to investigate the association between thyroid and erectile function in two different cohorts of subjects. The first one derives from the European Male Ageing Study (EMAS study), a multicentre survey performed on a sample of 3369 community-dwelling men aged 40-79years (mean 60±11years). The second cohort is a consecutive series of 3203 heterosexual male patients (mean age 51.8±13.0years) attending our Andrology and Sexual Medicine Outpatient Clinic for sexual dysfunction at the University of Florence (UNIFI study). In the EMAS study all subjects were tested for thyroid-stimulating hormone (TSH) and free thyroxine (FT4). Similarly, TSH levels were checked in all patients in the UNIFI study, while FT4 only when TSH resulted outside the reference range. Overt primary hyperthyroidism (reduced TSH and elevated FT4, according to the reference range) was found in 0.3 and 0.2% of EMAS and UNIFI study respectively. In both study cohorts, suppressed TSH levels were associated with erectile dysfunction (ED). Overt hyperthyroidism was associated with an increased risk of severe erectile dysfunction (ED, hazard ratio=14 and 16 in the EMAS and UNIFI study, respectively; both p",

keywords = "Erectile dysfunction, Hypoactive sexual desire, Testosterone, Thyroid hormones",

author = "G. Corona and F. Wu and G. Forti and DM Lee and O'Connor, {D. B.} and T. O'Neill and N. Pendleton and G. Bartfai and S. Boonen and F. Casanueva and J. Finn and A. Giwercman and Han, {T. S.} and I. Huhtaniemi and K. Kula and Lean, {M. E J} and M. Punab and D. Vanderschueren and Jannini, {E. A.} and E. Mannucci and M. Maggi and L. Petrone and H. Borghs and J. Slowikowska-Hilczer and R. Walczak-Jedrzejowska and A. Silman and P. Steer and A. Tajar and S. Pye and M. Ocampo and M. Lage and I. Foldesi and I. Fejes and P. Korrovitz and M. Jiang",

year = "2012",

month = oct,

doi = "10.1111/j.1365-2605.2012.01266.x",

language = "English",

volume = "35",

pages = "668--679",

journal = "International Journal of Andrology",

issn = "0105-6263",

publisher = "John Wiley & Sons Ltd",

number = "5",

}

Corona, G, Wu, F, Forti, G, Lee, DM, O'Connor, DB, O'Neill, T, Pendleton, N, Bartfai, G, Boonen, S, Casanueva, F, Finn, J, Giwercman, A, Han, TS, Huhtaniemi, I, Kula, K, Lean, MEJ, Punab, M, Vanderschueren, D, Jannini, EA, Mannucci, E, Maggi, M, Petrone, L, Borghs, H, Slowikowska-Hilczer, J, Walczak-Jedrzejowska, R, Silman, A, Steer, P, Tajar, A, Pye, S, Ocampo, M, Lage, M, Foldesi, I, Fejes, I, Korrovitz, P & Jiang, M 2012, 'Thyroid hormones and male sexual function', International Journal of Andrology, vol. 35, no. 5, pp. 668-679. https://doi.org/10.1111/j.1365-2605.2012.01266.x

TY - JOUR

T1 - Thyroid hormones and male sexual function

AU - Corona, G.

AU - Wu, F.

AU - Forti, G.

AU - Lee, DM

AU - O'Connor, D. B.

AU - O'Neill, T.

AU - Pendleton, N.

AU - Bartfai, G.

AU - Boonen, S.

AU - Casanueva, F.

AU - Finn, J.

AU - Giwercman, A.

AU - Han, T. S.

AU - Huhtaniemi, I.

AU - Kula, K.

AU - Lean, M. E J

AU - Punab, M.

AU - Vanderschueren, D.

AU - Jannini, E. A.

AU - Mannucci, E.

AU - Maggi, M.

AU - Petrone, L.

AU - Borghs, H.

AU - Slowikowska-Hilczer, J.

AU - Walczak-Jedrzejowska, R.

AU - Silman, A.

AU - Steer, P.

AU - Tajar, A.

AU - Pye, S.

AU - Ocampo, M.

AU - Lage, M.

AU - Foldesi, I.

AU - Fejes, I.

AU - Korrovitz, P.

AU - Jiang, M.

PY - 2012/10

Y1 - 2012/10

N2 - The role of thyroid hormones in the control of erectile functioning has been only superficially investigated. The aim of the present study was to investigate the association between thyroid and erectile function in two different cohorts of subjects. The first one derives from the European Male Ageing Study (EMAS study), a multicentre survey performed on a sample of 3369 community-dwelling men aged 40-79years (mean 60±11years). The second cohort is a consecutive series of 3203 heterosexual male patients (mean age 51.8±13.0years) attending our Andrology and Sexual Medicine Outpatient Clinic for sexual dysfunction at the University of Florence (UNIFI study). In the EMAS study all subjects were tested for thyroid-stimulating hormone (TSH) and free thyroxine (FT4). Similarly, TSH levels were checked in all patients in the UNIFI study, while FT4 only when TSH resulted outside the reference range. Overt primary hyperthyroidism (reduced TSH and elevated FT4, according to the reference range) was found in 0.3 and 0.2% of EMAS and UNIFI study respectively. In both study cohorts, suppressed TSH levels were associated with erectile dysfunction (ED). Overt hyperthyroidism was associated with an increased risk of severe erectile dysfunction (ED, hazard ratio=14 and 16 in the EMAS and UNIFI study, respectively; both p

AB - The role of thyroid hormones in the control of erectile functioning has been only superficially investigated. The aim of the present study was to investigate the association between thyroid and erectile function in two different cohorts of subjects. The first one derives from the European Male Ageing Study (EMAS study), a multicentre survey performed on a sample of 3369 community-dwelling men aged 40-79years (mean 60±11years). The second cohort is a consecutive series of 3203 heterosexual male patients (mean age 51.8±13.0years) attending our Andrology and Sexual Medicine Outpatient Clinic for sexual dysfunction at the University of Florence (UNIFI study). In the EMAS study all subjects were tested for thyroid-stimulating hormone (TSH) and free thyroxine (FT4). Similarly, TSH levels were checked in all patients in the UNIFI study, while FT4 only when TSH resulted outside the reference range. Overt primary hyperthyroidism (reduced TSH and elevated FT4, according to the reference range) was found in 0.3 and 0.2% of EMAS and UNIFI study respectively. In both study cohorts, suppressed TSH levels were associated with erectile dysfunction (ED). Overt hyperthyroidism was associated with an increased risk of severe erectile dysfunction (ED, hazard ratio=14 and 16 in the EMAS and UNIFI study, respectively; both p

KW - Erectile dysfunction

KW - Hypoactive sexual desire

KW - Testosterone

KW - Thyroid hormones

U2 - 10.1111/j.1365-2605.2012.01266.x

DO - 10.1111/j.1365-2605.2012.01266.x

M3 - Article

C2 - 22834774

SN - 0105-6263

VL - 35

SP - 668

EP - 679

JO - International Journal of Andrology

JF - International Journal of Andrology

IS - 5

ER -

Thyroid hormones and male sexual function

Abstract

Keywords

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