Thyroid hormones and male sexual function

G. Corona, F. Wu, G. Forti, DM Lee, D. B. O'Connor, T. O'Neill, N. Pendleton, G. Bartfai, S. Boonen, F. Casanueva, J. Finn, A. Giwercman, T. S. Han, I. Huhtaniemi, K. Kula, M. E J Lean, M. Punab, D. Vanderschueren, E. A. Jannini, E. MannucciM. Maggi, L. Petrone, H. Borghs, J. Slowikowska-Hilczer, R. Walczak-Jedrzejowska, A. Silman, P. Steer, A. Tajar, S. Pye, M. Ocampo, M. Lage, I. Foldesi, I. Fejes, P. Korrovitz, M. Jiang

Research output: Contribution to journalArticlepeer-review


The role of thyroid hormones in the control of erectile functioning has been only superficially investigated. The aim of the present study was to investigate the association between thyroid and erectile function in two different cohorts of subjects. The first one derives from the European Male Ageing Study (EMAS study), a multicentre survey performed on a sample of 3369 community-dwelling men aged 40-79years (mean 60±11years). The second cohort is a consecutive series of 3203 heterosexual male patients (mean age 51.8±13.0years) attending our Andrology and Sexual Medicine Outpatient Clinic for sexual dysfunction at the University of Florence (UNIFI study). In the EMAS study all subjects were tested for thyroid-stimulating hormone (TSH) and free thyroxine (FT4). Similarly, TSH levels were checked in all patients in the UNIFI study, while FT4 only when TSH resulted outside the reference range. Overt primary hyperthyroidism (reduced TSH and elevated FT4, according to the reference range) was found in 0.3 and 0.2% of EMAS and UNIFI study respectively. In both study cohorts, suppressed TSH levels were associated with erectile dysfunction (ED). Overt hyperthyroidism was associated with an increased risk of severe erectile dysfunction (ED, hazard ratio=14 and 16 in the EMAS and UNIFI study, respectively; both p
Original languageEnglish
Pages (from-to)668-679
Number of pages11
JournalInternational Journal of Andrology
Issue number5
Publication statusPublished - Oct 2012


  • Erectile dysfunction
  • Hypoactive sexual desire
  • Testosterone
  • Thyroid hormones


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