Thyroid scintigraphy differentiates subtypes of congenital hypothyroidism

Chris Worth, Beverly Hird, Lesley Tetlow, Neville Wright, Leena Patel, Indraneel Banerjee

Research output: Contribution to journalArticlepeer-review

53 Downloads (Pure)

Abstract

Introduction UK screening for congenital hypothyroidism (CH) is based on dried blood spot Thyroid Stimulating Hormone (TSH). Scintigraphy may identify CH subtypes classified as dysplasia, gland in situ (GIS) and ectopia, but is not performed in all centres. We retrospectively investigated the role of scintigraphy to identify CH subtypes in a single tertiary centre cohort.

Methods Babies who screened positive for CH between 2007 and 2017 were studied (n=418 of 534 783). Scintigraphy outcomes were correlated with TSH and levothyroxine dose. GIS patients were analysed for 3-year outcomes.

Results 303 patients started levothyroxine. Scintigraphy demonstrated three subtypes: GIS (n=139, 46%) ectopia (n=84, 28%) and dysplasia (n=80, 26%). Three-year follow up demonstrated permanence in 54% of 37 GIS cases.

Discussion Thyroid scintigraphy differentiates subtypes of CH and suggests a higher than expected proportion of patients with GIS and ectopia. CH is permanent in half of those with GIS.
Original languageEnglish
Pages (from-to)archdischild-2019-317665
JournalArchives of Disease in Childhood
Early online date14 Nov 2019
DOIs
Publication statusPublished - 14 Nov 2019

Fingerprint

Dive into the research topics of 'Thyroid scintigraphy differentiates subtypes of congenital hypothyroidism'. Together they form a unique fingerprint.

Cite this