Time-domain fluorescence lifetime imaging applied to biological tissue

Dan Elson, Jose Requejo-Isidro, Ian Munro, Fred Reavell, Jan Siegel, Klaus Suhling, Paul Tadrous, Richard Benninger, Peter Lanigan, James McGinty, Clifford Talbot, Bebhinn Treanor, Stephen Webb, Ann Sandison, Andrew Wallace, Dan Davis, John Lever, Mark Neil, David Philips, Gordon StampPaul French

    Research output: Contribution to journalArticlepeer-review


    Fluorescence lifetime imaging (FLIM) is a functional imaging methodology that can provide information, not only concerning the localisation of specific fluorophores, but also about the local fluorophore environment. It may be implemented in scanning confocal or multi-photon microscopes, or in wide-field microscopes and endoscopes. When applied to tissue autofluorescence, it reveals intrinsic excellent contrast between different types and states of tissue. This article aims to review our recent progress in developing time-domain FLIM technology for microscopy and endoscopy and applying it to biological tissue. © The Royal Society of Chemistry and Owner Societies 2004.
    Original languageEnglish
    Pages (from-to)795-801
    Number of pages6
    JournalPhotochemical and Photobiological Sciences
    Issue number8
    Publication statusPublished - Aug 2004


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