Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment

Hannah J Durrington; Gael O Gioan-tavernier; Robert J Maidstone; Karolina Krakowiak; Andrew S I Loudon; John F Blaikley; Stephen J Fowler; Dave Singh; Angela Simpson; David W Ray

doi:10.1164/rccm.201807-1289LE

Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment

Hannah J Durrington, Gael O Gioan-tavernier, Robert J Maidstone, Karolina Krakowiak, Andrew S I Loudon, John F Blaikley, Stephen J Fowler, Dave Singh, Angela Simpson, David W Ray

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Abstract

Asthma is characterised by strong time of day rhythms; symptoms worsen around 04:00 (1), coincident with increased airway narrowing, reflected by a reduced peak expiratory flow (PEF) or Forced Expiratory Volume in 1 second (FEV1) (2). Clinically useful biomarkers in asthma include sputum and blood eosinophils (3) and results from several small studies looking at circadian variation in airway inflammation in asthma are conflicting (4-9). Sputum eosinophil percentage is used to guide management decisions in severe asthma clinics (3); any diurnal variation in sputum eosinophilia could therefore influence the management of patients.
We studied circadian variation of blood and sputum eosinophils within a mild/moderate, atopic asthma cohort compared to healthy controls. We then retrospectively compared sputum eosinophil counts from a severe asthma clinic cohort in relation to time of day of collection (morning versus afternoon).

Original language	English
Pages (from-to)	1578-1581
Number of pages	4
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	198
Issue number	12
Early online date	29 Aug 2018
DOIs	https://doi.org/10.1164/rccm.201807-1289LE
Publication status	Published - 15 Dec 2018

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10.1164/rccm.201807-1289LE

Research Letter AJRCCM.clean versionAccepted author manuscript, 36.2 KB

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Durrington, H. J., Gioan-tavernier, G. O., Maidstone, R. J., Krakowiak, K., Loudon, A. S. I., Blaikley, J. F., Fowler, S. J., Singh, D., Simpson, A., & Ray, D. W. (2018). Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment. American Journal of Respiratory and Critical Care Medicine , 198(12), 1578-1581. https://doi.org/10.1164/rccm.201807-1289LE

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title = "Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment",

abstract = "Asthma is characterised by strong time of day rhythms; symptoms worsen around 04:00 (1), coincident with increased airway narrowing, reflected by a reduced peak expiratory flow (PEF) or Forced Expiratory Volume in 1 second (FEV1) (2). Clinically useful biomarkers in asthma include sputum and blood eosinophils (3) and results from several small studies looking at circadian variation in airway inflammation in asthma are conflicting (4-9). Sputum eosinophil percentage is used to guide management decisions in severe asthma clinics (3); any diurnal variation in sputum eosinophilia could therefore influence the management of patients. We studied circadian variation of blood and sputum eosinophils within a mild/moderate, atopic asthma cohort compared to healthy controls. We then retrospectively compared sputum eosinophil counts from a severe asthma clinic cohort in relation to time of day of collection (morning versus afternoon). ",

author = "Durrington, {Hannah J} and Gioan-tavernier, {Gael O} and Maidstone, {Robert J} and Karolina Krakowiak and Loudon, {Andrew S I} and Blaikley, {John F} and Fowler, {Stephen J} and Dave Singh and Angela Simpson and Ray, {David W}",

note = "Funding Information: H.J.D. is supported by an Asthma UK Senior Clinical Academic Development Award (AUK-SCAD-2013-229), the J P Moulton Charitable Foundation, a North West Lung Centre Charity project grant, and the University of Manchester Dean{\textquoteright}s Prize for Clinicians. R.J.M. is funded by grants from the Wellcome Trust (107849/Z/15/Z) and the Medical Research Council (MR/P023576/1). A.S.I.L. is a Wellcome Trust Investigator (107849/Z/15/Z). D.W.R. is a Wellcome Trust Investigator (107849/Z/15/Z) and received a Medical Research Council Program grant (MR/P023576/1). J.F.B. is funded by a Medical Research Council grant (MR/L006499/1). D.S. received research grants from Apellis, AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, Genentech, GlaxoSmithKline, Glenmark, Johnson and Johnson, Menarini, Mundipharma, Novartis, Peptinnovate, Pfizer, Pulmatrix, Skypharma, Teva, Therevance, and Verona. A.S. was supported by grants from the Medical Research Council, National Institute for Health Research, EU FP7, and the NIHR Manchester Biomedical Research Centre. Funding Information: Funding was provided by NIH P01 HL 108800 (E.D.A.), NIH R01 HL134802 (E.D.A.), and NIH R01 HL 102020 (R.H.) awards. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2018",

month = dec,

day = "15",

doi = "10.1164/rccm.201807-1289LE",

language = "English",

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pages = "1578--1581",

journal = "American Journal of Respiratory and Critical Care Medicine ",

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Durrington, HJ, Gioan-tavernier, GO, Maidstone, RJ, Krakowiak, K, Loudon, ASI , Blaikley, JF , Fowler, SJ , Singh, D , Simpson, A & Ray, DW 2018, 'Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment', American Journal of Respiratory and Critical Care Medicine , vol. 198, no. 12, pp. 1578-1581. https://doi.org/10.1164/rccm.201807-1289LE

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AU - Durrington, Hannah J

AU - Gioan-tavernier, Gael O

AU - Maidstone, Robert J

AU - Krakowiak, Karolina

AU - Loudon, Andrew S I

AU - Blaikley, John F

AU - Fowler, Stephen J

AU - Singh, Dave

AU - Simpson, Angela

AU - Ray, David W

N1 - Funding Information: H.J.D. is supported by an Asthma UK Senior Clinical Academic Development Award (AUK-SCAD-2013-229), the J P Moulton Charitable Foundation, a North West Lung Centre Charity project grant, and the University of Manchester Dean’s Prize for Clinicians. R.J.M. is funded by grants from the Wellcome Trust (107849/Z/15/Z) and the Medical Research Council (MR/P023576/1). A.S.I.L. is a Wellcome Trust Investigator (107849/Z/15/Z). D.W.R. is a Wellcome Trust Investigator (107849/Z/15/Z) and received a Medical Research Council Program grant (MR/P023576/1). J.F.B. is funded by a Medical Research Council grant (MR/L006499/1). D.S. received research grants from Apellis, AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, Genentech, GlaxoSmithKline, Glenmark, Johnson and Johnson, Menarini, Mundipharma, Novartis, Peptinnovate, Pfizer, Pulmatrix, Skypharma, Teva, Therevance, and Verona. A.S. was supported by grants from the Medical Research Council, National Institute for Health Research, EU FP7, and the NIHR Manchester Biomedical Research Centre. Funding Information: Funding was provided by NIH P01 HL 108800 (E.D.A.), NIH R01 HL134802 (E.D.A.), and NIH R01 HL 102020 (R.H.) awards. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2018/12/15

Y1 - 2018/12/15

N2 - Asthma is characterised by strong time of day rhythms; symptoms worsen around 04:00 (1), coincident with increased airway narrowing, reflected by a reduced peak expiratory flow (PEF) or Forced Expiratory Volume in 1 second (FEV1) (2). Clinically useful biomarkers in asthma include sputum and blood eosinophils (3) and results from several small studies looking at circadian variation in airway inflammation in asthma are conflicting (4-9). Sputum eosinophil percentage is used to guide management decisions in severe asthma clinics (3); any diurnal variation in sputum eosinophilia could therefore influence the management of patients. We studied circadian variation of blood and sputum eosinophils within a mild/moderate, atopic asthma cohort compared to healthy controls. We then retrospectively compared sputum eosinophil counts from a severe asthma clinic cohort in relation to time of day of collection (morning versus afternoon).

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M3 - Article

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JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

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ER -

Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment

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Investigation of REVERBalpha as a Therapeutic Target in Pulmonary Fibrosis.

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Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment

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Investigation of REVERBalpha as a Therapeutic Target in Pulmonary Fibrosis.

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