Time series clustering to examine presence of decrement in Parkinson’s finger-tapping bradykinesia

Zhibin Zhao, Hui Fang, Stefan Williams, Samuel D. Relton, Jane Alty, Alex J. Casson, David C. Wong

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

95 Downloads (Pure)

Abstract

Parkinson’s disease is diagnosed based on expert clinical observation of movements. One important clinical feature is decrement, whereby the range of finger motion decreases over the course of the observation. This decrement has been assumed to be linear but has not been examined closely.We previously developed a method to extract a time series representation of a finger-tapping clinical test from 137 smart- phone video recordings. Here, we show how the signal can be processed to visualize archetypal progression of decrement. We use k-means with features derived from dynamic time warping to compare similarity of time series. To generate the archetypal time series corresponding to each cluster, we apply both a simple arithmetic mean, and dynamic time warping barycenter averaging to the time series belonging to each cluster.Visual inspection of the cluster-average time series showed two main trends. These corresponded well with participants with no bradykinesia and participants with severe bradykinesia. The visualizations support the concept that decrement tends to present as a linear decrease in range of motion over time.Clinical relevance— Our work visually presents the archetypal types of bradykinesia amplitude decrement, as seen in the Parkinson’s finger-tapping test. We found two main patterns, one corresponding to no bradykinesia, and the other showing linear decrement over time.
Original languageEnglish
Title of host publication2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Pages780-783
DOIs
Publication statusE-pub ahead of print - 27 Aug 2020
Event2020 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) in conjunction with the 43rd Annual Conference of the Canadian Medical and Biological Engineering Society - Montreal, QC, Canada
Duration: 20 Jul 202024 Jul 2020

Conference

Conference2020 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) in conjunction with the 43rd Annual Conference of the Canadian Medical and Biological Engineering Society
Period20/07/2024/07/20

Fingerprint

Dive into the research topics of 'Time series clustering to examine presence of decrement in Parkinson’s finger-tapping bradykinesia'. Together they form a unique fingerprint.

Cite this