TY - JOUR
T1 - Time Spent in Hypoglycemia According to Age and Time of Day
T2 - Observations During Closed-Loop Insulin Delivery
AU - Alwan, Heba
AU - Ware, Julia
AU - Boughton, Charlotte K
AU - Wilinska, Malgorzata E
AU - Allen, Janet M
AU - Lakshman, Rama
AU - Nwokolo, Munachiso
AU - Hartnell, Sara
AU - Bally, Lia
AU - de Beaufort, Carine
AU - Besser, Rachel E J
AU - Campbell, Fiona M
AU - Davis, Nikki
AU - Denvir, Louise
AU - Evans, Mark L
AU - Fröhlich-Reiterer, Elke
AU - Ghatak, Atrayee
AU - Hofer, Sabine E
AU - Kapellen, Thomas M
AU - Leelarathna, Lalantha
AU - Mader, Julia K
AU - Narendran, Parth
AU - Rami-Mehrar, Birgit
AU - Tauschmann, Martin
AU - Thabit, Hood
AU - Thankamony, Ajay
AU - Hovorka, Roman
PY - 2023/7/1
Y1 - 2023/7/1
N2 - Objective: We aimed to assess whether percentage of time spent in hypoglycemia during closed-loop insulin delivery differs by age group and time of day. Methods: We retrospectively analyzed data from hybrid closed-loop studies involving young children (2-7 years), children and adolescents (8-18 years), adults (19-59 years), and older adults (≥60 years) with type 1 diabetes. Main outcome was time spent in hypoglycemia <3.9 mmol/L (<70 mg/dL). Eight weeks of data for 88 participants were analyzed. Results: Median time spent in hypoglycemia over the 24-h period was highest in children and adolescents (4.4% [interquartile range 2.4-5.0]) and very young children (4.0% [3.4-5.2]), followed by adults (2.7% [1.7-4.0]), and older adults (1.8% [1.2-2.2]); P < 0.001 for difference between age groups. Time spent in hypoglycemia during nighttime (midnight-05:59) was lower than during daytime (06:00-23:59) across all age groups. Conclusion: Time in hypoglycemia was highest in the pediatric age group during closed-loop insulin delivery. Hypoglycemia burden was lowest overnight across all age groups.
AB - Objective: We aimed to assess whether percentage of time spent in hypoglycemia during closed-loop insulin delivery differs by age group and time of day. Methods: We retrospectively analyzed data from hybrid closed-loop studies involving young children (2-7 years), children and adolescents (8-18 years), adults (19-59 years), and older adults (≥60 years) with type 1 diabetes. Main outcome was time spent in hypoglycemia <3.9 mmol/L (<70 mg/dL). Eight weeks of data for 88 participants were analyzed. Results: Median time spent in hypoglycemia over the 24-h period was highest in children and adolescents (4.4% [interquartile range 2.4-5.0]) and very young children (4.0% [3.4-5.2]), followed by adults (2.7% [1.7-4.0]), and older adults (1.8% [1.2-2.2]); P < 0.001 for difference between age groups. Time spent in hypoglycemia during nighttime (midnight-05:59) was lower than during daytime (06:00-23:59) across all age groups. Conclusion: Time in hypoglycemia was highest in the pediatric age group during closed-loop insulin delivery. Hypoglycemia burden was lowest overnight across all age groups.
KW - Adolescent
KW - Aged
KW - Child
KW - Child, Preschool
KW - Humans
KW - Blood Glucose
KW - Cross-Over Studies
KW - Diabetes Mellitus, Type 1/drug therapy
KW - Hypoglycemia/chemically induced
KW - Hypoglycemic Agents/therapeutic use
KW - Insulin/adverse effects
KW - Insulin Infusion Systems
KW - Insulin, Regular, Human/therapeutic use
KW - Retrospective Studies
KW - Treatment Outcome
KW - Young Adult
KW - Adult
KW - Middle Aged
UR - http://www.scopus.com/inward/record.url?scp=85164238820&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/91387a7c-36d6-380f-9b7f-c4323448150b/
U2 - 10.1089/dia.2023.0061
DO - 10.1089/dia.2023.0061
M3 - Article
C2 - 37229591
SN - 1520-9156
VL - 25
SP - 485
EP - 491
JO - Diabetes technology & therapeutics
JF - Diabetes technology & therapeutics
IS - 7
ER -
