TY - JOUR
T1 - Timed daily exercise remodels circadian rhythms in mice
AU - Hughes, Alun Thomas Lloyd
AU - Samuels, Rayna Eve
AU - Baño-Otálora, Beatriz
AU - Belle, Mino David Charles
AU - Wegner, Sven
AU - Guilding, Clare
AU - Northeast, Rebecca Catrin
AU - Loudon, Andrew Stewart Irvine
AU - Gigg, John
AU - Piggins, Hugh David
N1 - Funding Information:
We thank Carla Santos da Silva and Cheryl Petit as well as Dr. Sandrine Dupre and Dr. Andrea Power for technical assistance. This work was funded by project grants from the Biotechnology and Biological Sciences Research Council (BBSRC; BB/J003441/1 and BB/ M02329X/1 to H.D.P. and J.G. at the University of Manchester and BB/R019223/1 to H. D.P. and J.G. at the University of Bristol and the University of Manchester), a PhD studentship to S.W. from the University of Manchester Neuroscience Research Institute, a project grant from the Wellcome Trust (MA086352) to H.D.P. at the University of Manchester, and funding from the Human Frontiers of Science Programme (RGP0030/ 2015) and Wellcome Trust (107851/Z/15/Z) to A.S.I.L. at the University of Manchester.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/6/18
Y1 - 2021/6/18
N2 - Regular exercise is important for physical and mental health. An underexplored and intriguing property of exercise is its actions on the body’s 24 h or circadian rhythms. Molecular clock cells in the brain’s suprachiasmatic nuclei (SCN) use electrical and chemical signals to orchestrate their activity and convey time of day information to the rest of the brain and body. To date, the long-lasting effects of regular physical exercise on SCN clock cell coordination and communication remain unresolved. Utilizing mouse models in which SCN intercellular neuropeptide signaling is impaired as well as those with intact SCN neurochemical signaling, we examined how daily scheduled voluntary exercise (SVE) influenced behavioral rhythms and SCN molecular and neuronal activities. We show that in mice with disrupted neuropeptide signaling, SVE promotes SCN clock cell synchrony and robust 24 h rhythms in behavior. Interestingly, in both intact and neuropeptide signaling deficient animals, SVE reduces SCN neural activity and alters GABAergic signaling. These findings illustrate the potential utility of regular exercise as a long-lasting and effective non-invasive intervention in the elderly or mentally ill where circadian rhythms can be blunted and poorly aligned to the external world.
AB - Regular exercise is important for physical and mental health. An underexplored and intriguing property of exercise is its actions on the body’s 24 h or circadian rhythms. Molecular clock cells in the brain’s suprachiasmatic nuclei (SCN) use electrical and chemical signals to orchestrate their activity and convey time of day information to the rest of the brain and body. To date, the long-lasting effects of regular physical exercise on SCN clock cell coordination and communication remain unresolved. Utilizing mouse models in which SCN intercellular neuropeptide signaling is impaired as well as those with intact SCN neurochemical signaling, we examined how daily scheduled voluntary exercise (SVE) influenced behavioral rhythms and SCN molecular and neuronal activities. We show that in mice with disrupted neuropeptide signaling, SVE promotes SCN clock cell synchrony and robust 24 h rhythms in behavior. Interestingly, in both intact and neuropeptide signaling deficient animals, SVE reduces SCN neural activity and alters GABAergic signaling. These findings illustrate the potential utility of regular exercise as a long-lasting and effective non-invasive intervention in the elderly or mentally ill where circadian rhythms can be blunted and poorly aligned to the external world.
U2 - 10.1038/s42003-021-02239-2
DO - 10.1038/s42003-021-02239-2
M3 - Article
SN - 2399-3642
VL - 4
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 761
ER -