Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia

Timothy Somerville; Tim C P Somervaille

doi:10.1080/23723556.2015.1131355

Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia

Research output: Contribution to journal › Article › peer-review

Abstract

Tissue-inappropriate derepression of the mesenchymal transcription factor gene Forkhead Box C1 (FOXC1) occurs in approximately 20% of patients with acute myeloid leukemia. Through experimental and bioinformatics analyses, we have demonstrated this to be both functional (enhancing the myeloid lineage differentiation block characteristic of the disease) and adversely prognostic.

Original language	English
Pages (from-to)	e1131355
Journal	Molecular & cellular oncology
Volume	3
Issue number	2
DOIs	https://doi.org/10.1080/23723556.2015.1131355
Publication status	Published - Mar 2016

Keywords

Journal Article

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2015.1131355

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abstract = "Tissue-inappropriate derepression of the mesenchymal transcription factor gene Forkhead Box C1 (FOXC1) occurs in approximately 20% of patients with acute myeloid leukemia. Through experimental and bioinformatics analyses, we have demonstrated this to be both functional (enhancing the myeloid lineage differentiation block characteristic of the disease) and adversely prognostic.",

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AB - Tissue-inappropriate derepression of the mesenchymal transcription factor gene Forkhead Box C1 (FOXC1) occurs in approximately 20% of patients with acute myeloid leukemia. Through experimental and bioinformatics analyses, we have demonstrated this to be both functional (enhancing the myeloid lineage differentiation block characteristic of the disease) and adversely prognostic.

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Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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