Tissue remodelling in upper airways: Where is the link with lower airway remodelling?

J. B. Watelet, T. Van Zele, M. Gjomarkaj, G. W. Canonica, S. E. Dahlen, W. Fokkens, V. J. Lund, G. K. Scadding, J. Mullol, N. Papadopoulos, S. Bonini, M. L. Kowalski, P. Van Cauwenberge, J. Bousquet

    Research output: Contribution to journalArticlepeer-review


    Tissue remodelling reported in upper airways include epithelial hyperplasia, increased matrix deposition in the nasal or paranasal lining, matrix degradation and accumulation of plasma proteins. Genetic influences, foetal exposures and early life events may contribute to structural changes such as subepithelial fibrosis from an early age. Other structural alterations are related to duration of the disease and long-term uncontrolled inflammation. Structural changes may increase alteration of the protective functions of the upper airways namely by affecting mucociliary clearance and conditioning of inspired air. The sequences of tissue changes during wound repair of upper airway mucosa after surgery are illustrative of the complexicity of tissue modelling and remodelling and could be considered as an important source of information for a better understanding of the complex relationship between inflammatory reaction, of the subsequent tissue damages and fibroblast metabolism of upper airways. © 2006 The Authors.
    Original languageEnglish
    Pages (from-to)1249-1258
    Number of pages9
    JournalAllergy: European Journal of Allergy and Clinical Immunology
    Issue number11
    Publication statusPublished - Nov 2006


    • Airway
    • Chronic rhinosinusitis
    • Extracellular matrix
    • Fibrosis
    • Remodelling


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