Toll-like receptor 4 Asp299Gly polymorphism and rheumatoid arthritis: A replicative study in three different populations

G. Orozco, S. Morales, M. Á González-Gay, C. I. González Rugeles, G. Ramírez Quintero, Javier Martín

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Toll-like receptors (TLRs) polymorphisms have been extensively studied with regard to genetic predisposition to several human complex diseases. In this context, the role of TLR4 Asp299Gly in the pathogenesis of rheumatoid arthritis (RA) is not clear. The aim of this study was to test the possible implication of this polymorphism in the susceptibility to RA. We genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in three different populations from Granada (Southern Spain), Lugo (Northern Spain), and Colombia. We did not find statistically significant differences in the distribution of alleles and genotypes in any of the cohorts under study. Our data, together with those from other groups, do not support a relevant role of TLR4 Asp299Gly polymorphism in the susceptibility to RA.
    Original languageEnglish
    Pages (from-to)205-207
    Number of pages2
    JournalInmunología
    Volume24
    Issue number2
    Publication statusPublished - Apr 2005

    Keywords

    • Polymorphism
    • Rheumatoid arthritis
    • Toll-like receptor 4 gene

    Fingerprint

    Dive into the research topics of 'Toll-like receptor 4 Asp299Gly polymorphism and rheumatoid arthritis: A replicative study in three different populations'. Together they form a unique fingerprint.

    Cite this