TY - JOUR
T1 - Topical radiant heating in wound healing: An experimental study in a donor site wound model
AU - Mcgrouther, Duncan
AU - Khan, Aadil A.
AU - Banwell, Paul E.
AU - Bakker, Martijn C.
AU - Gillespie, Patrick G.
AU - McGrouther, Douglas A.
AU - Roberts, Anthony H N
PY - 2004
Y1 - 2004
N2 - The importance of temperature in the wound-healing process is rapidly being recognised as a novel way in which to manipulate the wound-healing environment. In this study, we aimed to investigate the direct effect of topical radiant heating (TRH), using a novel bandaging system (Warm-UpTM, Arizant Healthcare Inc., Eden Prairie MN, USA; Augustine Medical, USA), on wound healing at a physiological and cellular level. Experimental bandages were positioned over split-thickness skin graft donor site wounds of 12 patients undergoing graft harvesting from the anterior thigh. The experimental group (n = 6) underwent intermittent heating for 5 hours (three 1-hour heating cycles at 38oC, separated by two 1-hour rest periods), whilst the control group (n = 6) received no radiant heating. Physiological blood-flow recordings both in the control group and the topical radiant heat cohort were undertaken using Laser Doppler Imaging (LDI). Skin biopsies were obtained at identical time points, and immunohistochemical analysis was undertaken using antibodies against neutrophils (NP57), lymphocytes (CD3) and macrophages (CD68). We found that TRH significantly increased local dermal blood flow (P
AB - The importance of temperature in the wound-healing process is rapidly being recognised as a novel way in which to manipulate the wound-healing environment. In this study, we aimed to investigate the direct effect of topical radiant heating (TRH), using a novel bandaging system (Warm-UpTM, Arizant Healthcare Inc., Eden Prairie MN, USA; Augustine Medical, USA), on wound healing at a physiological and cellular level. Experimental bandages were positioned over split-thickness skin graft donor site wounds of 12 patients undergoing graft harvesting from the anterior thigh. The experimental group (n = 6) underwent intermittent heating for 5 hours (three 1-hour heating cycles at 38oC, separated by two 1-hour rest periods), whilst the control group (n = 6) received no radiant heating. Physiological blood-flow recordings both in the control group and the topical radiant heat cohort were undertaken using Laser Doppler Imaging (LDI). Skin biopsies were obtained at identical time points, and immunohistochemical analysis was undertaken using antibodies against neutrophils (NP57), lymphocytes (CD3) and macrophages (CD68). We found that TRH significantly increased local dermal blood flow (P
KW - LDI
KW - Lymphocyte
KW - Skin graft
KW - TRH
KW - Wound
U2 - 10.1111/j.1742-4801.2004.00065.x
DO - 10.1111/j.1742-4801.2004.00065.x
M3 - Article
SN - 1742-4801
VL - 1
SP - 233
EP - 240
JO - International wound journal
JF - International wound journal
IS - 4
ER -