Topological Optimisation of Scaffolds for Tissue Engineering

Paulo Jorge Da Silva bartolo, Henrique A Almeida, Paulo J B??rtolo

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Advanced additive manufacturing technologies, namely Biomanufacturing, are being used to fabricate scaffolds with controlled architecture for tissue engineering applications. These technologies combined with computer-aided design (CAD) enable to produce three-dimensional structures layer-by-layer in a multitude of materials. Actual prediction of the effective mechanical properties of scaffolds produced by Biomanufacturing, is very important for tissue engineering applications. A novel computer based technique for scaffold design is topological optimisation. Topological optimisation is a form of ???shape??? optimisation, usually referred to as ???layout??? optimisation. The goal of topological optimisation is to find the best use of material for a body that is subjected to either a single load or a multiple load distribution. This paper proposes a topological optimisation scheme in order to obtain the ideal topological architectures of scaffolds, maximising its mechanical behaviour.
    Original languageEnglish
    Pages (from-to)298-306
    Number of pages9
    JournalProcedia Engineering
    Volume59
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Computacional tecnologies
    • Scaffolds.
    • tissue engineering
    • Topological optimisation

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