TY - JOUR
T1 - Total disc replacement devices: Structure, material, fabrication, and properties
AU - Song, Guangsheng
AU - Qian, Zhihui
AU - Wang, Kunyang
AU - Liu, Jing
AU - Wei, Yuyang
AU - Galbusera, Fabio
AU - Zou, Zhenmin
AU - Wilke, Hans-Joachim
AU - Ren, Luquan
AU - Ren, Lei
PY - 2023/12/1
Y1 - 2023/12/1
N2 - The intervertebral disc (IVD) is an important component of the human spine that maintains physiological motion and distributes loads. Single- or multi-segment degeneration occurs alongside normal aging or damage to the human spine. These phenomena may in turn cause persistent pain and disability. This is among the major musculoskeletal system diseases worldwide. Total disc replacement (TDR) is one effective approach to treating symptomatic degenerative disc disease (DDD). Numerous ideas for TDR devices have been proposed. These devices seek to reproduce the biomechanical function of the functional spinal unit (FSU). However, the complex human physiological environment and long-term operational conditions pose substantial challenges that affect the structural design, material properties, and process strategies associated with TDR devices. This review introduces the main advantages and scientific challenges associated with existing TDR devices. Furthermore, a novel strategy to fabricate TDR devices by integrating cutting-edge technologies (e.g., bionic technology, functionally graded materials, and additive manufacturing) is described. How this approach can help to restore biofunction and improve performance is discussed. Finally, the future research directions of TDR devices are proposed. The research may provide new inspiration for the innovative design and manufacture of next-generation engineered TDR devices.
AB - The intervertebral disc (IVD) is an important component of the human spine that maintains physiological motion and distributes loads. Single- or multi-segment degeneration occurs alongside normal aging or damage to the human spine. These phenomena may in turn cause persistent pain and disability. This is among the major musculoskeletal system diseases worldwide. Total disc replacement (TDR) is one effective approach to treating symptomatic degenerative disc disease (DDD). Numerous ideas for TDR devices have been proposed. These devices seek to reproduce the biomechanical function of the functional spinal unit (FSU). However, the complex human physiological environment and long-term operational conditions pose substantial challenges that affect the structural design, material properties, and process strategies associated with TDR devices. This review introduces the main advantages and scientific challenges associated with existing TDR devices. Furthermore, a novel strategy to fabricate TDR devices by integrating cutting-edge technologies (e.g., bionic technology, functionally graded materials, and additive manufacturing) is described. How this approach can help to restore biofunction and improve performance is discussed. Finally, the future research directions of TDR devices are proposed. The research may provide new inspiration for the innovative design and manufacture of next-generation engineered TDR devices.
KW - Biomaterial
KW - Total disc replacement
KW - Bionic
KW - Additive manufacturing
KW - Mechanical properties
U2 - 10.1016/j.pmatsci.2023.101189
DO - 10.1016/j.pmatsci.2023.101189
M3 - Article
SN - 0079-6425
VL - 140
JO - Progress In Materials Science
JF - Progress In Materials Science
M1 - 101189
ER -