Total synthesis of a 20-deoxybryostatin

Anthony P Green; Alan T L Lee; Eric J Thomas

doi:10.1039/c1cc12332g

Total synthesis of a 20-deoxybryostatin

Anthony P Green, Alan T L Lee, Eric J Thomas

Research output: Contribution to journal › Article › peer-review

Abstract

The 20-deoxybryostatin 40 has been prepared using a modified Julia olefination to form the 16,17-double-bond, followed by macrolactonisation, selective deprotection and oxidation. This is the first total synthesis of a 20-deoxybryostatin.

Original language	English
Pages (from-to)	7200-2
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	25
DOIs	https://doi.org/10.1039/c1cc12332g https://doi.org/10.1039/c1cc12332g
Publication status	Published - 7 Jul 2011

Keywords

Bryostatins
Ethers
Oxidation-Reduction
Substrate Specificity
Journal Article
Research Support, Non-U.S. Gov't

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title = "Total synthesis of a 20-deoxybryostatin",

abstract = "The 20-deoxybryostatin 40 has been prepared using a modified Julia olefination to form the 16,17-double-bond, followed by macrolactonisation, selective deprotection and oxidation. This is the first total synthesis of a 20-deoxybryostatin.",

keywords = "Bryostatins, Ethers, Oxidation-Reduction, Substrate Specificity, Journal Article, Research Support, Non-U.S. Gov't",

author = "Green, {Anthony P} and Lee, {Alan T L} and Thomas, {Eric J}",

note = "This journal is {\textcopyright} The Royal Society of Chemistry 2011",

year = "2011",

month = jul,

day = "7",

doi = "10.1039/c1cc12332g",

language = "English",

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journal = "Chemical Communications",

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T1 - Total synthesis of a 20-deoxybryostatin

AU - Green, Anthony P

AU - Lee, Alan T L

AU - Thomas, Eric J

N1 - This journal is © The Royal Society of Chemistry 2011

PY - 2011/7/7

Y1 - 2011/7/7

N2 - The 20-deoxybryostatin 40 has been prepared using a modified Julia olefination to form the 16,17-double-bond, followed by macrolactonisation, selective deprotection and oxidation. This is the first total synthesis of a 20-deoxybryostatin.

AB - The 20-deoxybryostatin 40 has been prepared using a modified Julia olefination to form the 16,17-double-bond, followed by macrolactonisation, selective deprotection and oxidation. This is the first total synthesis of a 20-deoxybryostatin.

KW - Bryostatins

KW - Ethers

KW - Oxidation-Reduction

KW - Substrate Specificity

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1039/c1cc12332g

DO - 10.1039/c1cc12332g

M3 - Article

C2 - 21614401

SN - 1359-7345

VL - 47

SP - 7200

EP - 7202

JO - Chemical Communications

JF - Chemical Communications

IS - 25

ER -

Total synthesis of a 20-deoxybryostatin

Abstract

Keywords

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