Total synthesis of a 20-deoxybryostatin

Anthony P Green, Alan T L Lee, Eric J Thomas

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The 20-deoxybryostatin 40 has been prepared using a modified Julia olefination to form the 16,17-double-bond, followed by macrolactonisation, selective deprotection and oxidation. This is the first total synthesis of a 20-deoxybryostatin.

    Original languageEnglish
    Pages (from-to)7200-2
    Number of pages3
    JournalChemical Communications
    Volume47
    Issue number25
    DOIs
    Publication statusPublished - 7 Jul 2011

    Keywords

    • Bryostatins
    • Ethers
    • Oxidation-Reduction
    • Substrate Specificity
    • Journal Article
    • Research Support, Non-U.S. Gov't

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