Total synthesis of the Fusarium toxin equisetin

Darren Dixon; Lisa T. Burke; Darren J. Dixon; Steven V. Ley; Félix Rodríguez

doi:10.1039/b411350k

Total synthesis of the Fusarium toxin equisetin

Darren Dixon
, Lisa T. Burke
, Darren J. Dixon
, Steven V. Ley
, Félix Rodríguez

Research output: Contribution to journal › Article › peer-review

Abstract

A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels-Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted γ,δ-unsaturated β-ketothioester.

Original language	English
Pages (from-to)	274-280
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	3
Issue number	2
DOIs	https://doi.org/10.1039/b411350k
Publication status	Published - 21 Jan 2005

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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title = "Total synthesis of the Fusarium toxin equisetin",

abstract = "A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels-Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted γ,δ-unsaturated β-ketothioester.",

author = "Darren Dixon and Burke, \{Lisa T.\} and Dixon, \{Darren J.\} and Ley, \{Steven V.\} and F{\'e}lix Rodr{\'i}guez",

year = "2005",

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doi = "10.1039/b411350k",

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AU - Dixon, Darren

AU - Burke, Lisa T.

AU - Dixon, Darren J.

AU - Ley, Steven V.

AU - Rodríguez, Félix

PY - 2005/1/21

Y1 - 2005/1/21

N2 - A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels-Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted γ,δ-unsaturated β-ketothioester.

AB - A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels-Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted γ,δ-unsaturated β-ketothioester.

U2 - 10.1039/b411350k

DO - 10.1039/b411350k

M3 - Article

SN - 1477-0520

VL - 3

SP - 274

EP - 280

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 2

ER -

Total synthesis of the Fusarium toxin equisetin

Abstract

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