Towards a unified approach for the determination of the bioaccessibility of organic pollutants

Chris D. Collins (Lead), Stephen Lowe, Mark Craggs, Sonia Garcia-Alcega, Katerina Kademoglou

Research output: Contribution to journalArticlepeer-review


Bioaccessibility studies have been widely used as a research tool to determine the potential human exposure to ingested contaminants. More recently they have been practically applied for soil borne toxic elements. This paper reviews the application of bioaccessibility tests across a range of organic pollutants and contaminated matrices. Important factors are reported to be: the physiological relevance of the test, the components in the gut media, the size fraction chosen for the test and whether it contains a sorptive sink. The bioaccessibility is also a function of the composition of the matrix (e.g. organic carbon content of soils) and the physico-chemical characteristics of the pollutant under test. Despite the widespread use of these tests, there are a large number of formats used and very few validation studies with animal models. We propose a unified format for a bioaccessibility test for organic pollutants. The robustness of this test should first be confirmed through inter laboratory comparison, then tested in-vivo.
Original languageEnglish
Pages (from-to)24 - 31
Number of pages7
JournalEnvironment International
Publication statusPublished - May 2015


  • Bioaccessibility
  • Contaminated land
  • Brownfield
  • Sustainability
  • Geochemistry
  • In vitro methods
  • Human health

Research Beacons, Institutes and Platforms

  • Henry Royce Institute


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