Toxicity study of isolated polypeptide from wool hydrolysate

Jiashen Li, Yi Li, Yu Zhang, Xuan Liu, Zheng Zhao, Jing Zhang, Yanxia Han, Dangxia Zhou

Research output: Contribution to journalArticlepeer-review


The cytotoxicity of wool polypeptide has been evaluated by both cell and animal models. Wool was dissolved in sodium hydroxide solution, the pH value of the solution was adjusted to 5.55 and the precipitate was harvested as wool polypeptide. The spray-dried polypeptide was collected as powders and characterized by SEM, FTIR and TG–DSC. The cell culturing results showed that wool polypeptide had no obvious negative effect on cell viability in vitro. Both acute oral toxicity and subacute 30-day oral toxicology studies showed that wool polypeptide had no influence on body weight, feed consumption, blood chemistry, and hematology at any dose levels. There were no treatment related findings on gross or detailed necroscopy, organ weights, organ/body weight ratios and histology. Our study indicated the absence of toxicity in wool polypeptide and supported its safe use as a food ingredient or drug carrier.
Original languageEnglish
Pages (from-to)338-345
Number of pages8
JournalFood and Chemical Toxicology
Publication statusPublished - 2013


Dive into the research topics of 'Toxicity study of isolated polypeptide from wool hydrolysate'. Together they form a unique fingerprint.

Cite this