Toxins-antitoxins: Plasmid maintenance, programmed cell death, and cell cycle arrest

Finbarr Hayes

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Antibiotic resistance, virulence, and other plasmids in bacteria use toxin-antitoxin gene pairs to ensure their persistence during host replication. The toxin-antitoxin system eliminates plasmid-free cells that emerge as a result of segregation or replication defects and contributes to intra- and interspecies plasmid dissemination. Chromosomal homologs of toxin-antitoxin genes are widely distributed in pathogenic and other bacteria and induce reversible cell cycle arrest or programmed cell death in response to starvation or other adverse conditions. The dissection of the interaction of the toxins with intracellular targets and the elucidation of the tertiary structures of toxin-antitoxin complexes have provided exciting insights into toxin-antitoxin behavior.
    Original languageEnglish
    Pages (from-to)1496-1499
    Number of pages3
    JournalScience
    Volume301
    Issue number5639
    DOIs
    Publication statusPublished - 12 Sept 2003

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