Trace metals and astrocytes physiology and pathophysiology

Baoman Li, Weiyang Yu, Alexei Verkhratsky

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Abstract

Several trace metals, including iron, copper, manganese and zinc are essential for normal function of the nervous system. Both deficiency and excessive accumulation of these metals trigger neuropathological developments. The central nervous system (CNS) is in possession of dedicated homeostatic system that removes, accumulates, stores and releases these metals to fulfil nervous tissue demand. This system is mainly associated with astrocytes that act as dynamic reservoirs for trace metals, these being a part of a global system of CNS ionostasis. Here we overview physiological and pathophysiological aspects of astrocyte-cantered trace metals regulation.

Original languageEnglish
Article number102843
JournalCell calcium
Volume118
Early online date4 Jan 2024
DOIs
Publication statusPublished - 1 Mar 2024

Keywords

  • Astrocyte
  • Copper
  • Iron
  • Manganese
  • Metal transporters
  • Transferrin
  • Zinc

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