Trafficking of adhesion and growth factor receptors and their effector kinases

Christina Schoenherr, Margaret C. Frame, Adam Byron

Research output: Contribution to journalArticlepeer-review


Cell adhesion to macromolecules in the microenvironment is essential for the development and maintenance of tissues, and its dysregulation can lead to a range of disease states, including inflammation, fibrosis, and cancer. The biomechanical and biochemical mechanisms that mediate cell adhesion rely on signaling by a range of effector proteins, including kinases and associated scaffolding proteins. The intracellular trafficking of these must be tightly controlled in space and time to enable effective cell adhesion and microenvironmental sensing and to integrate cell adhesion with, and compartmentalize it from, other cellular processes, such as gene transcription, protein degradation, and cell division. Delivery of adhesion receptors and signaling proteins from the plasma membrane to unanticipated subcellular locales is revealing novel biological functions. Here, we review the expected and unexpected trafficking, and sites of activity, of adhesion and growth factor receptors and intracellular kinase partners as we begin to appreciate the complexity and diversity of their spatial regulation.
Original languageEnglish
Pages (from-to)29-58
Number of pages30
JournalAnnual Review of Cell and Developmental Biology
Publication statusPublished - 6 Oct 2018


  • adhesion receptors
  • endosomes
  • growth factor receptors
  • kinases
  • nucleus
  • protein trafficking


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