Transcriptional regulation by WT1 in development

Stefan G E Roberts

doi:10.1016/j.gde.2005.08.004

Transcriptional regulation by WT1 in development

Stefan G E Roberts

Research output: Contribution to journal › Article › peer-review

Abstract

The Wilms' tumour suppressor protein, WT1, plays a central role in the development of the genitourinary system and also other organs and tissues. WT1 can act as a transcriptional regulator or as an RNA processing factor in an isoform-dependent manner. The mechanisms that are used by WT1 to regulate transcription, and its associated target genes have been difficult to study, in part because the transcription function of WT1 is highly context-dependent. Recent studies have provided new insights into how WT1 achieves this specificity and have uncovered new target genes that are regulated by WT1 during development. In addition, ongoing studies of transgenic animals and analyses in kidney explant systems have revealed further roles for WT1 in development. © 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	542-547
Number of pages	5
Journal	Current Opinion in Genetics and Development
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.gde.2005.08.004
Publication status	Published - Oct 2005

Access to Document

10.1016/j.gde.2005.08.004

Cite this

@article{a31476babedf4532b61c9af07f5921ae,

title = "Transcriptional regulation by WT1 in development",

abstract = "The Wilms' tumour suppressor protein, WT1, plays a central role in the development of the genitourinary system and also other organs and tissues. WT1 can act as a transcriptional regulator or as an RNA processing factor in an isoform-dependent manner. The mechanisms that are used by WT1 to regulate transcription, and its associated target genes have been difficult to study, in part because the transcription function of WT1 is highly context-dependent. Recent studies have provided new insights into how WT1 achieves this specificity and have uncovered new target genes that are regulated by WT1 during development. In addition, ongoing studies of transgenic animals and analyses in kidney explant systems have revealed further roles for WT1 in development. {\textcopyright} 2005 Elsevier Ltd. All rights reserved.",

author = "Roberts, {Stefan G E}",

year = "2005",

month = oct,

doi = "10.1016/j.gde.2005.08.004",

language = "English",

volume = "15",

pages = "542--547",

journal = "Current Opinion in Genetics and Development",

issn = "1879-0380",

publisher = "Elsevier BV",

number = "5",

}

TY - JOUR

T1 - Transcriptional regulation by WT1 in development

AU - Roberts, Stefan G E

PY - 2005/10

Y1 - 2005/10

N2 - The Wilms' tumour suppressor protein, WT1, plays a central role in the development of the genitourinary system and also other organs and tissues. WT1 can act as a transcriptional regulator or as an RNA processing factor in an isoform-dependent manner. The mechanisms that are used by WT1 to regulate transcription, and its associated target genes have been difficult to study, in part because the transcription function of WT1 is highly context-dependent. Recent studies have provided new insights into how WT1 achieves this specificity and have uncovered new target genes that are regulated by WT1 during development. In addition, ongoing studies of transgenic animals and analyses in kidney explant systems have revealed further roles for WT1 in development. © 2005 Elsevier Ltd. All rights reserved.

AB - The Wilms' tumour suppressor protein, WT1, plays a central role in the development of the genitourinary system and also other organs and tissues. WT1 can act as a transcriptional regulator or as an RNA processing factor in an isoform-dependent manner. The mechanisms that are used by WT1 to regulate transcription, and its associated target genes have been difficult to study, in part because the transcription function of WT1 is highly context-dependent. Recent studies have provided new insights into how WT1 achieves this specificity and have uncovered new target genes that are regulated by WT1 during development. In addition, ongoing studies of transgenic animals and analyses in kidney explant systems have revealed further roles for WT1 in development. © 2005 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.gde.2005.08.004

DO - 10.1016/j.gde.2005.08.004

M3 - Article

C2 - 16099645

SN - 1879-0380

VL - 15

SP - 542

EP - 547

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

IS - 5

ER -

Transcriptional regulation by WT1 in development

Abstract

Access to Document

Fingerprint

Cite this