TY - JOUR
T1 - Transcriptional regulation by WT1 in development
AU - Roberts, Stefan G E
PY - 2005/10
Y1 - 2005/10
N2 - The Wilms' tumour suppressor protein, WT1, plays a central role in the development of the genitourinary system and also other organs and tissues. WT1 can act as a transcriptional regulator or as an RNA processing factor in an isoform-dependent manner. The mechanisms that are used by WT1 to regulate transcription, and its associated target genes have been difficult to study, in part because the transcription function of WT1 is highly context-dependent. Recent studies have provided new insights into how WT1 achieves this specificity and have uncovered new target genes that are regulated by WT1 during development. In addition, ongoing studies of transgenic animals and analyses in kidney explant systems have revealed further roles for WT1 in development. © 2005 Elsevier Ltd. All rights reserved.
AB - The Wilms' tumour suppressor protein, WT1, plays a central role in the development of the genitourinary system and also other organs and tissues. WT1 can act as a transcriptional regulator or as an RNA processing factor in an isoform-dependent manner. The mechanisms that are used by WT1 to regulate transcription, and its associated target genes have been difficult to study, in part because the transcription function of WT1 is highly context-dependent. Recent studies have provided new insights into how WT1 achieves this specificity and have uncovered new target genes that are regulated by WT1 during development. In addition, ongoing studies of transgenic animals and analyses in kidney explant systems have revealed further roles for WT1 in development. © 2005 Elsevier Ltd. All rights reserved.
UR - https://www.scopus.com/pages/publications/24344478550
U2 - 10.1016/j.gde.2005.08.004
DO - 10.1016/j.gde.2005.08.004
M3 - Article
C2 - 16099645
SN - 1879-0380
VL - 15
SP - 542
EP - 547
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 5
ER -