Transcriptomic Profiling of Human Choriodecidua During Term Labor: Inflammation as a Key Driver of Labor.

Gillian L Stephen, Sylvia Lui, Sarah A Hamilton, Clare L Tower, Lynda K Harris, Adam Stevens, Rebecca L Jones

    Research output: Contribution to journalArticlepeer-review


    PROBLEM: Inflammation is a driver of labor in myometrium and cervix; however, the involvement of decidua is poorly defined. We have reported decidual leukocyte infiltration prior to and during labor; the regulators of these inflammatory processes are unknown. METHOD OF STUDY: Choriodecidua RNA obtained after term labor or elective cesarean delivery was applied to Affymetrix GeneChips. Pathway analysis and gene validation were performed. RESULTS: Extensive inflammatory activation was identified in choriodecidua following labor, predominantly upregulation of genes regulating leukocyte trafficking and cytokine signalling. Genes governing cell fate, tissue remodelling, and translation were also altered. Upregulation of candidate genes (ICAM1, CXCR4, CD44, TLR4, SOCS3, BCL2A, and IDO) was confirmed. NFκB, STAT1&3, HMGB1, and miRNA-21, miRNA-46, miRNA-141, and miRNA-200 were predicted upstream regulators. CONCLUSION: This study confirms inflammatory processes are major players in labor events in choriodecidua, as in other gestational tissues. Suppressing uterine inflammation is likely to be critical for arresting premature labor.
    Original languageEnglish
    Pages (from-to)36-55
    Number of pages19
    JournalAmerican journal of reproductive immunology (New York, N.Y. : 1989)
    Issue number1
    Publication statusPublished - 4 Oct 2014


    • Chemokines
    • choriodecidua
    • miRNAs
    • pathway analysis
    • transcription factors


    Dive into the research topics of 'Transcriptomic Profiling of Human Choriodecidua During Term Labor: Inflammation as a Key Driver of Labor.'. Together they form a unique fingerprint.

    Cite this