Transforming growth factor β and diastolic left ventricular dysfunction after heart transplantation: Echocardiographic and histologic evidence

Tarek M. Aziz; Malcolm I. Burgess; Philip S. Haselton; Nizar A. Yonan; Ian V. Hutchinson

doi:10.1016/S1053-2498(02)00657-5

Transforming growth factor β and diastolic left ventricular dysfunction after heart transplantation: Echocardiographic and histologic evidence

Tarek M. Aziz, Malcolm I. Burgess, Philip S. Haselton, Nizar A. Yonan, Ian V. Hutchinson

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The mechanism for chronic left ventricular diastolic dysfunction in the non-rejecting cardiac allograft has not been fully studied. Objectives: The purposes of this study were to analyze the significance and frequency of left ventricular diastolic dysfunction after heart transplantation and to examine the involvement of fibrotic cytokines (transforming growth factor β [TGF-β]) in development of clinical and echocardiographic changes in cardiac allograft recipients. Methods: We studied 152 heart transplant recipients who had survived for at least 24 months. We compared histopathologic findings (staining of endomyocardial biopsy specimens using hematoxylin and eosin, and polyclonal antibodies expressed as TGF-β score), left ventricular function (Doppler echocardiography), and clinical course (New York Heart Association [NYHA] status). We classified patients into Group 1 (n = 41 recipients) with a restrictive filling pattern, mitral deceleration time (MDT)

Original language	English
Pages (from-to)	663-673
Number of pages	10
Journal	Journal of Heart and Lung Transplantation
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/S1053-2498(02)00657-5
Publication status	Published - 1 Jun 2003

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title = "Transforming growth factor β and diastolic left ventricular dysfunction after heart transplantation: Echocardiographic and histologic evidence",

abstract = "Background: The mechanism for chronic left ventricular diastolic dysfunction in the non-rejecting cardiac allograft has not been fully studied. Objectives: The purposes of this study were to analyze the significance and frequency of left ventricular diastolic dysfunction after heart transplantation and to examine the involvement of fibrotic cytokines (transforming growth factor β [TGF-β]) in development of clinical and echocardiographic changes in cardiac allograft recipients. Methods: We studied 152 heart transplant recipients who had survived for at least 24 months. We compared histopathologic findings (staining of endomyocardial biopsy specimens using hematoxylin and eosin, and polyclonal antibodies expressed as TGF-β score), left ventricular function (Doppler echocardiography), and clinical course (New York Heart Association [NYHA] status). We classified patients into Group 1 (n = 41 recipients) with a restrictive filling pattern, mitral deceleration time (MDT)",

author = "Aziz, {Tarek M.} and Burgess, {Malcolm I.} and Haselton, {Philip S.} and Yonan, {Nizar A.} and Hutchinson, {Ian V.}",

year = "2003",

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doi = "10.1016/S1053-2498(02)00657-5",

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TY - JOUR

T1 - Transforming growth factor β and diastolic left ventricular dysfunction after heart transplantation: Echocardiographic and histologic evidence

AU - Aziz, Tarek M.

AU - Burgess, Malcolm I.

AU - Haselton, Philip S.

AU - Yonan, Nizar A.

AU - Hutchinson, Ian V.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Background: The mechanism for chronic left ventricular diastolic dysfunction in the non-rejecting cardiac allograft has not been fully studied. Objectives: The purposes of this study were to analyze the significance and frequency of left ventricular diastolic dysfunction after heart transplantation and to examine the involvement of fibrotic cytokines (transforming growth factor β [TGF-β]) in development of clinical and echocardiographic changes in cardiac allograft recipients. Methods: We studied 152 heart transplant recipients who had survived for at least 24 months. We compared histopathologic findings (staining of endomyocardial biopsy specimens using hematoxylin and eosin, and polyclonal antibodies expressed as TGF-β score), left ventricular function (Doppler echocardiography), and clinical course (New York Heart Association [NYHA] status). We classified patients into Group 1 (n = 41 recipients) with a restrictive filling pattern, mitral deceleration time (MDT)

AB - Background: The mechanism for chronic left ventricular diastolic dysfunction in the non-rejecting cardiac allograft has not been fully studied. Objectives: The purposes of this study were to analyze the significance and frequency of left ventricular diastolic dysfunction after heart transplantation and to examine the involvement of fibrotic cytokines (transforming growth factor β [TGF-β]) in development of clinical and echocardiographic changes in cardiac allograft recipients. Methods: We studied 152 heart transplant recipients who had survived for at least 24 months. We compared histopathologic findings (staining of endomyocardial biopsy specimens using hematoxylin and eosin, and polyclonal antibodies expressed as TGF-β score), left ventricular function (Doppler echocardiography), and clinical course (New York Heart Association [NYHA] status). We classified patients into Group 1 (n = 41 recipients) with a restrictive filling pattern, mitral deceleration time (MDT)

U2 - 10.1016/S1053-2498(02)00657-5

DO - 10.1016/S1053-2498(02)00657-5

M3 - Article

C2 - 12821163

SN - 1053-2498

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EP - 673

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

IS - 6

ER -

Transforming growth factor β and diastolic left ventricular dysfunction after heart transplantation: Echocardiographic and histologic evidence

Abstract

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