Transforming growth factor-12 polymorphism and systemic lupus erythematosus

A. Alansari, A. Hajeer, L.S. Teh, A Bayat, AM Hinks, A. Mysercough, A. Gul, M. Inanc, J. Ordi-Ros, WER Ollier

    Research output: Contribution to journalArticlepeer-review


    OBJECTIVE: To determine whether transforming growth factor-beta2 (TGF-beta2) gene polymorphism is associated with systemic lupus erythematosus (SLE) susceptibility. TGF-beta is a multifunctional family of cytokines important in tissue repair, inflammation and immunoregulation. SLE is thought to be a T cell dependent autoimmune disorder with T cell dysfunction. Due to its known suppressive effects on interleukin 2 dependent T cell growth, TGF-beta2 is considered to be a candidate SLE susceptibility gene. Furthermore, SLE has been linked with a region to which the TGF-beta2 gene has been mapped. METHODS: Association studies were performed in 3 case-control populations, from Spain. Turkey, and UK, using a TGF-beta2 5'-untranslated region (5'-UTR) 4 base pair (bp) insertion polymorphism. Genotyping was performed using fluorescent labeled polymerase chain reaction product sizing. Results. No significant differences were detected in TGF-beta2 5'-UTR polymorphism allele frequencies between SLE patients and matched controls in the 3 populations studied. CONCLUSION. The 4 bp insertion polymorphism within the TGF-beta2 gene does not appear to be associated with SLE. However, this does not rule out the possible involvement of TGF-beta2 in the disease pathogenesis
    Original languageEnglish
    JournalJournal of Rheumatology
    Volume29, 6
    Publication statusPublished - 2002


    • Alleles
    • Base Sequence
    • Case-Control Studies
    • Chi-Square Distribution
    • Cohort Studies
    • Comparative Study
    • Cytokines
    • Disease
    • epidemiology
    • Female
    • Gene Frequency
    • Genetic Predisposition to Disease
    • genetics
    • Great Britain
    • Human
    • Inflammation
    • Lupus Erythematosus,Systemic
    • Male
    • methods
    • Molecular Sequence Data
    • Multicenter Studies
    • Polymerase Chain Reaction
    • Polymorphism (Genetics)
    • Probability
    • Reference Values
    • Sensitivity and Specificity
    • Spain
    • Transforming Growth Factor beta
    • Turkey


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