Transforming growth factor beta and myocardial dysfunction following heart transplantation

Tarek Aziz, Rasheed A. Saad, Malcolm Burgess, Nizar Yonan, Philip Hasleton, Ian V. Hutchinson

    Research output: Contribution to journalArticlepeer-review


    Objective: We analyzed the role of transforming growth factor-beta (TGF-β), a fibrogenic cytokine, in the development of left ventricular diastolic dysfunction following heart transplantation. Methods: We studied 152 heart transplant recipients who had survived for at least 24 months. We compared histopathological findings (staining of endomyocardial biopsy specimens using Heamatoxlin Eosin and polyclonal antibodies), left ventricular function (Doppler echocardiography) and clinical course (NYHA status}. Patients are classified into group A (n=56 recipients) with immunohistochemical TGF-β staining score >7 and group B (n=96 recipients) with a staining score 50% stenosis) was 17 and 29% for recipients in group A compared to 4 and 6% for recipients in group B at 3 and 5 years follow-up, respectively (P=0.01 and P=0.005, respectively). Conclusions: TGF-β expression in cardiac allografts is associated with impaired graft function and limited survival. The pathogenesis of diastolic dysfunction may be an aberrant repair process following rejection due to increased TGF-β expression in transplant recipients. Copyright © 2001 Elsevier Science B.V.
    Original languageEnglish
    Pages (from-to)177-186
    Number of pages9
    JournalEuropean Journal of Cardio-Thoracic Surgery
    Issue number1
    Publication statusPublished - 2001


    • Echocardiography
    • Heart transplantation
    • Left ventricular dysfunction
    • Transforming growth factor-beta


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