Transforming growth factor beta (TGFβ) and keloid disease

Jagajeevan Jagadeesan; Ardeshir Bayat

doi:10.1016/j.ijsu.2006.04.007

Transforming growth factor beta (TGFβ) and keloid disease

Jagajeevan Jagadeesan, Ardeshir Bayat

Research output: Contribution to journal › Article › peer-review

Abstract

Keloids are benign fibroproliferative diseases of unknown aetiology. They occur as a result of derangement of the normal wound healing process in susceptible individuals. Although several factors have been postulated in the aetiopathogenesis of this condition, there has been growing evidence to suggest a role for Transforming Growth Factor beta (TGFβ) family members in its pathogenesis. TGFβ has also been found to be associated with fibrotic diseases affecting different organs of the body including liver, kidney, lung as well as skin. In this review article, we will discuss the morphology and mechanism of action of TGFβ and its isoforms and present the most up to date literature discussing the role of TGFβ isoforms, their receptors, and intracellular signalling pathways (the SMAD pathway) in the pathogenesis of keloid disease. Understanding the role of TGFβ in keloid disease could lead to the development of clinically useful therapeutic modalities for treatment of this condition. © 2006.

Original language	English
Pages (from-to)	278-285
Number of pages	7
Journal	International Journal of Surgery
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/j.ijsu.2006.04.007
Publication status	Published - Aug 2007

Keywords

Fibrosis
Keloid disease
Skin scarring
Transforming growth factor β

Access to Document

10.1016/j.ijsu.2006.04.007

Cite this

@article{6377210c4b464cde955e39df83f54943,

title = "Transforming growth factor beta (TGFβ) and keloid disease",

abstract = "Keloids are benign fibroproliferative diseases of unknown aetiology. They occur as a result of derangement of the normal wound healing process in susceptible individuals. Although several factors have been postulated in the aetiopathogenesis of this condition, there has been growing evidence to suggest a role for Transforming Growth Factor beta (TGFβ) family members in its pathogenesis. TGFβ has also been found to be associated with fibrotic diseases affecting different organs of the body including liver, kidney, lung as well as skin. In this review article, we will discuss the morphology and mechanism of action of TGFβ and its isoforms and present the most up to date literature discussing the role of TGFβ isoforms, their receptors, and intracellular signalling pathways (the SMAD pathway) in the pathogenesis of keloid disease. Understanding the role of TGFβ in keloid disease could lead to the development of clinically useful therapeutic modalities for treatment of this condition. {\textcopyright} 2006.",

keywords = "Fibrosis, Keloid disease, Skin scarring, Transforming growth factor β",

author = "Jagajeevan Jagadeesan and Ardeshir Bayat",

year = "2007",

month = aug,

doi = "10.1016/j.ijsu.2006.04.007",

language = "English",

volume = "5",

pages = "278--285",

journal = "International Journal of Surgery",

issn = "1743-9191",

publisher = "Wolters Kluwer Health Inc",

number = "4",

}

TY - JOUR

T1 - Transforming growth factor beta (TGFβ) and keloid disease

AU - Jagadeesan, Jagajeevan

AU - Bayat, Ardeshir

PY - 2007/8

Y1 - 2007/8

N2 - Keloids are benign fibroproliferative diseases of unknown aetiology. They occur as a result of derangement of the normal wound healing process in susceptible individuals. Although several factors have been postulated in the aetiopathogenesis of this condition, there has been growing evidence to suggest a role for Transforming Growth Factor beta (TGFβ) family members in its pathogenesis. TGFβ has also been found to be associated with fibrotic diseases affecting different organs of the body including liver, kidney, lung as well as skin. In this review article, we will discuss the morphology and mechanism of action of TGFβ and its isoforms and present the most up to date literature discussing the role of TGFβ isoforms, their receptors, and intracellular signalling pathways (the SMAD pathway) in the pathogenesis of keloid disease. Understanding the role of TGFβ in keloid disease could lead to the development of clinically useful therapeutic modalities for treatment of this condition. © 2006.

AB - Keloids are benign fibroproliferative diseases of unknown aetiology. They occur as a result of derangement of the normal wound healing process in susceptible individuals. Although several factors have been postulated in the aetiopathogenesis of this condition, there has been growing evidence to suggest a role for Transforming Growth Factor beta (TGFβ) family members in its pathogenesis. TGFβ has also been found to be associated with fibrotic diseases affecting different organs of the body including liver, kidney, lung as well as skin. In this review article, we will discuss the morphology and mechanism of action of TGFβ and its isoforms and present the most up to date literature discussing the role of TGFβ isoforms, their receptors, and intracellular signalling pathways (the SMAD pathway) in the pathogenesis of keloid disease. Understanding the role of TGFβ in keloid disease could lead to the development of clinically useful therapeutic modalities for treatment of this condition. © 2006.

KW - Fibrosis

KW - Keloid disease

KW - Skin scarring

KW - Transforming growth factor β

U2 - 10.1016/j.ijsu.2006.04.007

DO - 10.1016/j.ijsu.2006.04.007

M3 - Article

SN - 1743-9191

VL - 5

SP - 278

EP - 285

JO - International Journal of Surgery

JF - International Journal of Surgery

IS - 4

ER -

Transforming growth factor beta (TGFβ) and keloid disease

Abstract

Keywords

Access to Document

Fingerprint

Cite this