Abstract
Background: Malaria transmission through blood transfusion is an accidental but
preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services.
Objectives: This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asymptomatic blood donors and the effectiveness of screening methods used based on the available literature.
Data sources: PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1982 to 10th of October 2017.
Study eligibility: All peer-reviewed original research articles describing the prevalence of malaria parasitaemia in blood donors with different diagnostic methods were included.
Methods: The random-effects model was applied to assess the effects of heterogeneity among the selected studies. Incoherence and heterogeneity between studies were quantified by I2 index and Cochran’s Q test. Publication and population bias was assessed with funnel plots and Egger’s regression asymmetry test. All statistical analyses were performed using Stata (Version 2.7.2).
Results: Seventy-one studies from 21 countries, five continents were included in the present systematic review. The median prevalence of malaria parasitaemia among 984,975 asymptomatic healthy blood donors was 10.54%, 5.36% and 0.38% by microscopy, molecular methods (PCR) and rapid diagnostic tests, respectively. The most commonly detected Plasmodium species was P. falciparum.
Conclusion: This systematic review demonstrates that compared with other transfusion significant transfusion associated infections especially in sub-Saharan Africa. Future work must aim to understand the clinical significance of transfusion-transmitted malaria in malariaendemic settings. linked infections i.e. HIV, HCV and HBV, transfusion-transmitted malaria is one of the most
preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services.
Objectives: This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asymptomatic blood donors and the effectiveness of screening methods used based on the available literature.
Data sources: PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1982 to 10th of October 2017.
Study eligibility: All peer-reviewed original research articles describing the prevalence of malaria parasitaemia in blood donors with different diagnostic methods were included.
Methods: The random-effects model was applied to assess the effects of heterogeneity among the selected studies. Incoherence and heterogeneity between studies were quantified by I2 index and Cochran’s Q test. Publication and population bias was assessed with funnel plots and Egger’s regression asymmetry test. All statistical analyses were performed using Stata (Version 2.7.2).
Results: Seventy-one studies from 21 countries, five continents were included in the present systematic review. The median prevalence of malaria parasitaemia among 984,975 asymptomatic healthy blood donors was 10.54%, 5.36% and 0.38% by microscopy, molecular methods (PCR) and rapid diagnostic tests, respectively. The most commonly detected Plasmodium species was P. falciparum.
Conclusion: This systematic review demonstrates that compared with other transfusion significant transfusion associated infections especially in sub-Saharan Africa. Future work must aim to understand the clinical significance of transfusion-transmitted malaria in malariaendemic settings. linked infections i.e. HIV, HCV and HBV, transfusion-transmitted malaria is one of the most
| Original language | English |
|---|---|
| Journal | Open Forum Infectious Diseases |
| Early online date | 11 Jun 2019 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- Transfusion associated infections
- transfusion medicine
- Plasmodium
- systematic review
- blood donor
