Transient self-assembly of molecular nanostructures driven by chemical fuels

F. della Sala, S. Neri, S. Maiti, J.L.-Y. Chen, L.J. Prins

Research output: Contribution to journalArticlepeer-review


Over the past decades, chemists have mastered the art of assembling small molecules into complex nanostructures using non-covalent interactions. The driving force for self-assembly is thermodynamics: the self-assembled structure is more stable than the separate components. However, biological self-assembly processes are often energetically uphill and require the consumption of chemical energy. This allows nature to control the activation and duration of chemical functions associated with the assembled state. Synthetic chemical systems that operate in the same way are essential for creating the next generation of intelligent, adaptive materials, nanomachines and delivery systems. This review focuses on synthetic molecular nanostructures which self-assemble under dissipative conditions. The chemical function associated with the transient assemblies is operational as long as chemical fuel is present.
Original languageEnglish
Pages (from-to)27-33
JournalCurrent Opinion in Biotechnology
Early online date22 Jan 2017
Publication statusPublished - 2017


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