Transition-metal-free direct arylation of anilines

Tracey Pirali, Fengzhi Zhang, Anna H. Miller, Jenna L. Head, Donald McAusland, Michael F. Greaney

    Research output: Contribution to journalArticlepeer-review


    Aryne arylation: A new method of direct arylation is reported for aniline substrates. The reaction uses benzyne to synthesize a variety of aminobiaryls under mild conditions (see scheme), requiring no stoichiometric metalation or transition-metal catalysis. An ene mechanism is implicated, and conveys excellent functional group tolerance relative to metal-mediated processes. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Original languageEnglish
    Pages (from-to)1006-1009
    Number of pages3
    JournalAngewandte Chemie - International Edition
    Issue number4
    Publication statusPublished - 23 Jan 2012


    • anilines
    • arynes
    • C-H bond activation


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