Translating knowledge on best practice into improving quality of RRT care: a systematic review of implementation strategies

Sabine N van der Veer, Kitty J Jager, Azri M Nache, Donald Richardson, Janet Hegarty, Cécile Couchoud, Nicolette F de Keizer, Charles R V Tomson

Research output: Contribution to journalArticlepeer-review


Recent studies showed wide variation in the extent to which guidelines and other types of best practice have been implemented as part of routine health care. This is also true for the delivery of renal replacement therapy (RRT) for ESRD patients. Increasing uptake of best practice within such complex care systems requires an understanding of implementation strategies and specific quality improvement (QI) techniques. Therefore, we systematically reviewed over 5000 titles published since 1990 and included papers describing planned attempts to accelerate uptake of best RRT practice into daily care. This resulted in a list of 93 QI initiatives, categorized in order to expedite shared learning. The majority of the initiatives were executed within the domains of vascular access, nutrition, and anemia management. Strategies oriented at patients were most common and many initiatives pre-defined an improvement target before starting implementation. Of the 93 initiatives, 22 were sufficiently robust methodologically to be analyzed in more detail. Our results tend to support previous findings that multifaceted strategies are more effective than single strategies. Improving our understanding of how to successfully implement best practice can inform system-level change and is the only way to close the gap between knowledge on what works and the actual care delivered to ESRD patients. Research into implementation, using specific QI techniques, should therefore be given priority in future.

Original languageEnglish
Pages (from-to)1021-34
Number of pages14
JournalKidney International
Issue number10
Publication statusPublished - Nov 2011


  • Benchmarking
  • Chi-Square Distribution
  • Delivery of Health Care, Integrated
  • Evidence-Based Medicine
  • Guideline Adherence
  • Humans
  • Kidney Failure, Chronic
  • Outcome and Process Assessment (Health Care)
  • Patient Selection
  • Practice Guidelines as Topic
  • Quality Improvement
  • Renal Replacement Therapy
  • Treatment Outcome
  • Journal Article
  • Review


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