Projects per year
Abstract
coli cells, both lead to excretion of cytoplasmic protein (ECP). Condition-specific metabolomic and proteomic analyses combined with genetic knockouts, indicate a role of both the large mechanosensitive channel (MscL) and the alternative ribosome-rescue factor A (ArfA) in ECP. Collectively, the findings indicate that the MscL-dependent protein excretion is positively regulated in response to both osmotic and arfA-mediated translational stress.
Original language | English |
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Article number | e02118-17 |
Journal | mBio |
Volume | 9 |
Issue number | 1 |
Early online date | 30 Jan 2018 |
DOIs | |
Publication status | Published - 2018 |
Research Beacons, Institutes and Platforms
- Manchester Institute of Biotechnology
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Dive into the research topics of 'Translation stress positively regulates MscL-dependent excretion of cytoplasmic proteins'. Together they form a unique fingerprint.Projects
- 2 Finished
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Manchester Synthetic Biology Research Centre for Fine and Speciality Chemicals
Scrutton, N. (PI), Azapagic, A. (CoI), Balmer, A. (CoI), Barran, P. (CoI), Breitling, R. (CoI), Delneri, D. (CoI), Dixon, N. (CoI), Faulon, J.-L. (CoI), Flitsch, S. (CoI), Goble, C. (CoI), Goodacre, R. (CoI), Hay, S. (CoI), Kell, D. (CoI), Leys, D. (CoI), Lloyd, J. (CoI), Lockyer, N. (CoI), Martin, P. (CoI), Micklefield, J. (CoI), Munro, A. (CoI), Pedrosa Mendes, P. (CoI), Randles, S. (CoI), Salehi Yazdi, F. (CoI), Shapira, P. (CoI), Takano, E. (CoI), Turner, N. (CoI) & Winterburn, J. (CoI)
14/11/14 → 13/05/20
Project: Research
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Development and Application of Next Generation Synthetic Biology Tools
Dixon, N. (PI)
1/11/13 → 31/10/19
Project: Research
Equipment
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Biological Mass Spectrometry (BioMS) Facility
Knight, D. (Platform Lead), Warwood, S. (Senior Technical Specialist), Selley, J. (Technical Specialist), Taylor, G. (Technical Specialist), Fullwood, P. (Technical Specialist), Keevill, E.-J. (Senior Technician) & Allsey, J. (Technician)
FBMH Platform Sciences, Enabling Technologies & InfrastructureFacility/equipment: Facility